Next Article in Journal
Neglschisandrins A-B: Two New Dibenzocyclooctene Lignans from Schisandra neglecta
Next Article in Special Issue
Prodrugs for the Treatment of Neglected Diseases
Previous Article in Journal
Regioselectivity and Tautomerism of Novel Five-Membered Ring Nitrogen Heterocycles Formed via Cyclocondensation of Acylthiosemicarbazides
Previous Article in Special Issue
Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs
Molecules 2008, 13(3), 519-547; doi:10.3390/molecules13030519
Review

Prodrugs for Amines

1,2,* , 3
 and 3
Received: 14 December 2007; in revised form: 25 February 2008 / Accepted: 25 February 2008 / Published: 3 March 2008
(This article belongs to the collection Prodrugs)
Download PDF [165 KB, uploaded 18 June 2014]
Abstract: The purpose of this work is to review the published strategies for the productionof prodrugs of amines. The review is divided in two main groups of approaches: those thatrely on enzymatic activation and those that take advantage of physiological chemicalconditions for release of the drugs. A compilation of the most important approaches ispresented in the form of a table, where the main advantages and disadvantages of eachstrategy are also referred.
Keywords: Prodrugs; amines; enzymatic activation; chemical activation Prodrugs; amines; enzymatic activation; chemical activation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Simplício, A.L.; Clancy, J.M.; Gilmer, J.F. Prodrugs for Amines. Molecules 2008, 13, 519-547.

AMA Style

Simplício AL, Clancy JM, Gilmer JF. Prodrugs for Amines. Molecules. 2008; 13(3):519-547.

Chicago/Turabian Style

Simplício, Ana L.; Clancy, John M.; Gilmer, John F. 2008. "Prodrugs for Amines." Molecules 13, no. 3: 519-547.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert