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Molecules 2008, 13(3), 519-547; doi:10.3390/molecules13030519

Prodrugs for Amines

1,2,* , 3
1 Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República – EAN, 2780-157 Oeiras, Portugal 2 IBET, Apartado 12, 2781-901 Oeiras, Portugal 3 School of Pharmacy, Trinity College, Dublin 2, Ireland
* Author to whom correspondence should be addressed.
Received: 14 December 2007 / Revised: 25 February 2008 / Accepted: 25 February 2008 / Published: 3 March 2008
(This article belongs to the collection Prodrugs)
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The purpose of this work is to review the published strategies for the productionof prodrugs of amines. The review is divided in two main groups of approaches: those thatrely on enzymatic activation and those that take advantage of physiological chemicalconditions for release of the drugs. A compilation of the most important approaches ispresented in the form of a table, where the main advantages and disadvantages of eachstrategy are also referred.
Keywords: Prodrugs; amines; enzymatic activation; chemical activation Prodrugs; amines; enzymatic activation; chemical activation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Simplício, A.L.; Clancy, J.M.; Gilmer, J.F. Prodrugs for Amines. Molecules 2008, 13, 519-547.

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