Molecules 2008, 13(3), 519-547; doi:10.3390/molecules13030519
Review

Prodrugs for Amines

Ana L. Simplício 1,2,* email, John M. Clancy 3 email and John F. Gilmer 3 email
1 Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República – EAN, 2780-157 Oeiras, Portugal 2 IBET, Apartado 12, 2781-901 Oeiras, Portugal 3 School of Pharmacy, Trinity College, Dublin 2, Ireland
* Author to whom correspondence should be addressed.
Received: 14 December 2007; in revised form: 25 February 2008 / Accepted: 25 February 2008 / Published: 3 March 2008
(This article belongs to the Special Issue Prodrugs)
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Abstract: The purpose of this work is to review the published strategies for the productionof prodrugs of amines. The review is divided in two main groups of approaches: those thatrely on enzymatic activation and those that take advantage of physiological chemicalconditions for release of the drugs. A compilation of the most important approaches ispresented in the form of a table, where the main advantages and disadvantages of eachstrategy are also referred.
Keywords: Prodrugs; amines; enzymatic activation; chemical activation

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Cite This Article

MDPI and ACS Style

Simplício, A.L.; Clancy, J.M.; Gilmer, J.F. Prodrugs for Amines. Molecules 2008, 13, 519-547.

AMA Style

Simplício AL, Clancy JM, Gilmer JF. Prodrugs for Amines. Molecules. 2008; 13(3):519-547.

Chicago/Turabian Style

Simplício, Ana L.; Clancy, John M.; Gilmer, John F. 2008. "Prodrugs for Amines." Molecules 13, no. 3: 519-547.

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