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Molecules 2008, 13(3), 519-547; doi:10.3390/molecules13030519

Prodrugs for Amines

1
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República – EAN, 2780-157 Oeiras, Portugal
2
IBET, Apartado 12, 2781-901 Oeiras, Portugal
3
School of Pharmacy, Trinity College, Dublin 2, Ireland
*
Author to whom correspondence should be addressed.
Received: 14 December 2007 / Revised: 25 February 2008 / Accepted: 25 February 2008 / Published: 3 March 2008
(This article belongs to the Special Issue Prodrugs)

Abstract

The purpose of this work is to review the published strategies for the productionof prodrugs of amines. The review is divided in two main groups of approaches: those thatrely on enzymatic activation and those that take advantage of physiological chemicalconditions for release of the drugs. A compilation of the most important approaches ispresented in the form of a table, where the main advantages and disadvantages of eachstrategy are also referred.
Keywords: Prodrugs; amines; enzymatic activation; chemical activation Prodrugs; amines; enzymatic activation; chemical activation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Simplício, A.L.; Clancy, J.M.; Gilmer, J.F. Prodrugs for Amines. Molecules 2008, 13, 519-547.

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