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Molecules 2008, 13(2), 255-266; doi:10.3390/molecules13020255
Article

New Benzoyl Glucosides and Cytotoxic Pterosin Sesquiterpenes from Pteris ensiformis Burm.

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1 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan 2 Department of Biotechnology, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan
* Author to whom correspondence should be addressed.
Received: 18 January 2008 / Revised: 4 February 2008 / Accepted: 4 February 2008 / Published: 5 February 2008
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Abstract

Three new compounds: 2R,3R-pterosin L 3-O-β-D-glucopyranoside (1), β-Dxylopyranosyl(1→2)-7-O-benzoyl-β-D-glucopyranoside (2) and 4-O-benzoyl-β-D-xylopyranosyl(1→2)-7-O-benzoyl-β-D-glucopyranoside (3), together with nine knowncompounds, were isolated from the ethyl acetate extract of Pteris ensiformis. 5-[2-Hydroxyethylidene]-2(5H)-furanone (4), which had been synthesized, was isolated fromnatural sources for the first time. The structures of all isolated compounds were determinedon the basis of mass and spectroscopic evidence. Compound 1 and pterosin B (5) showcytotoxicity against HL 60 cells (human leukemia) with the IC50 values of 3.7 and 8.7μg/mL, respectively.
Keywords: Pteris ensiformis; pterosin B; human leukemia Pteris ensiformis; pterosin B; human leukemia
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Chen, Y.-H.; Chang, F.-R.; Lu, M.-C.; Hsieh, P.-W.; Wu, M.-J.; Du, Y.-C.; Wu, Y.-C. New Benzoyl Glucosides and Cytotoxic Pterosin Sesquiterpenes from Pteris ensiformis Burm.. Molecules 2008, 13, 255-266.

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