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Molecules 2008, 13(2), 255-266; doi:10.3390/molecules13020255

New Benzoyl Glucosides and Cytotoxic Pterosin Sesquiterpenes from Pteris ensiformis Burm.

1 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan 2 Department of Biotechnology, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan
* Author to whom correspondence should be addressed.
Received: 18 January 2008 / Revised: 4 February 2008 / Accepted: 4 February 2008 / Published: 5 February 2008
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Three new compounds: 2R,3R-pterosin L 3-O-β-D-glucopyranoside (1), β-Dxylopyranosyl(1→2)-7-O-benzoyl-β-D-glucopyranoside (2) and 4-O-benzoyl-β-D-xylopyranosyl(1→2)-7-O-benzoyl-β-D-glucopyranoside (3), together with nine knowncompounds, were isolated from the ethyl acetate extract of Pteris ensiformis. 5-[2-Hydroxyethylidene]-2(5H)-furanone (4), which had been synthesized, was isolated fromnatural sources for the first time. The structures of all isolated compounds were determinedon the basis of mass and spectroscopic evidence. Compound 1 and pterosin B (5) showcytotoxicity against HL 60 cells (human leukemia) with the IC50 values of 3.7 and 8.7μg/mL, respectively.
Keywords: Pteris ensiformis; pterosin B; human leukemia Pteris ensiformis; pterosin B; human leukemia
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, Y.-H.; Chang, F.-R.; Lu, M.-C.; Hsieh, P.-W.; Wu, M.-J.; Du, Y.-C.; Wu, Y.-C. New Benzoyl Glucosides and Cytotoxic Pterosin Sesquiterpenes from Pteris ensiformis Burm.. Molecules 2008, 13, 255-266.

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