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Molecules 2008, 13(11), 2900-2907; doi:10.3390/molecules13112900
Article

Ferroquine, an Ingenious Antimalarial Drug –Thoughts on the Mechanism of Action

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Received: 22 October 2008; in revised form: 14 November 2008 / Accepted: 18 November 2008 / Published: 20 November 2008
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Abstract: Ferroquine (FQ or SR97193) is a novel antimalarial drug candidate, currently in development at Sanofi-Aventis. In contrast to conventional drugs, FQ is the first organometallic drug: a ferrocenyl group covalently flanked by a 4-aminoquinoline and a basic alkylamine. FQ is able to overcome the CQ resistance problem, an important limit to the control of Plasmodium falciparum, the principal causative agent of malaria. After fifteen years of effort, it is now possible to propose a multifactorial mechanism of action of FQ by its capacity to target lipids, to inhibit the formation of hemozoin and to generate reactive oxygen species.
Keywords: Malaria; Bioorganometallics; Ferroquine; Mechanism of action; Resistance Malaria; Bioorganometallics; Ferroquine; Mechanism of action; Resistance
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MDPI and ACS Style

Dubar, F.; Khalife, J.; Brocard, J.; Dive, D.; Biot, C. Ferroquine, an Ingenious Antimalarial Drug –Thoughts on the Mechanism of Action. Molecules 2008, 13, 2900-2907.

AMA Style

Dubar F, Khalife J, Brocard J, Dive D, Biot C. Ferroquine, an Ingenious Antimalarial Drug –Thoughts on the Mechanism of Action. Molecules. 2008; 13(11):2900-2907.

Chicago/Turabian Style

Dubar, Faustine; Khalife, Jamal; Brocard, Jacques; Dive, Daniel; Biot, Christophe. 2008. "Ferroquine, an Ingenious Antimalarial Drug –Thoughts on the Mechanism of Action." Molecules 13, no. 11: 2900-2907.



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