Next Article in Journal
Macrocyclic Trichothecene Production by the Fungus Epibiont of Baccharis Coridifolia
Next Article in Special Issue
Synthesis and Evaluation of Non-peptidic Cysteine Protease Inhibitors of P. falciparum Derived from Etacrynic Acid
Previous Article in Journal
Halogenated Terpenes and a C15-Acetogenin from the Marine Red Alga Laurencia saitoi
Molecules 2008, 13(11), 2900-2907; doi:10.3390/molecules13112900

Ferroquine, an Ingenious Antimalarial Drug –Thoughts on the Mechanism of Action

1 Université des Sciences et Technologies de Lille, Unité de Catalyse et Chimie du Solide – UMR CNRS 8181, Ecole Nationale Supérieure de Chimie de Lille, Bâtiment C7, B.P. 90108, 59652 Villeneuve d' Ascq cedex, France 2 Inserm U547, Institut Pasteur, 1 rue du Pr Calmette, B.P. 245, 59019 Lille Cedex, France
* Author to whom correspondence should be addressed.
Received: 22 October 2008 / Revised: 14 November 2008 / Accepted: 18 November 2008 / Published: 20 November 2008
Download PDF [156 KB, uploaded 18 June 2014]


Ferroquine (FQ or SR97193) is a novel antimalarial drug candidate, currently in development at Sanofi-Aventis. In contrast to conventional drugs, FQ is the first organometallic drug: a ferrocenyl group covalently flanked by a 4-aminoquinoline and a basic alkylamine. FQ is able to overcome the CQ resistance problem, an important limit to the control of Plasmodium falciparum, the principal causative agent of malaria. After fifteen years of effort, it is now possible to propose a multifactorial mechanism of action of FQ by its capacity to target lipids, to inhibit the formation of hemozoin and to generate reactive oxygen species.
Keywords: Malaria; Bioorganometallics; Ferroquine; Mechanism of action; Resistance Malaria; Bioorganometallics; Ferroquine; Mechanism of action; Resistance
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Dubar, F.; Khalife, J.; Brocard, J.; Dive, D.; Biot, C. Ferroquine, an Ingenious Antimalarial Drug –Thoughts on the Mechanism of Action. Molecules 2008, 13, 2900-2907.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert