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Molecules 2008, 13(11), 2796-2803; doi:10.3390/molecules13112796
Article

A New Phloroglucinol Diglycoside Derivative from Hypericum japonicum Thunb.

1,2
,
2
,
1,*  and 1,*
1 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, 103. Wenhua Road Shenhe District, Shenyang, Liaoning 110016, P.R. China 2 Shenzhen Institute for Drug Control, Shenzhen, Guangdong 518029, P.R. China
* Authors to whom correspondence should be addressed.
Received: 30 September 2008 / Revised: 27 October 2008 / Accepted: 4 November 2008 / Published: 7 November 2008
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Abstract

A new phloroglucinol diglycoside 1, together with eight known compounds, were isolated from Hypericum japonicum Thunb. The structure of the new compound 1 was determined by spectroscopic methods to be 4,6-dimethyl-5-O-[α-L-rhamnopyranosyl-(1→6)-α-D-glucopyranosyl] multifidol. Different solvent extracts of Hypericum japonicum Thunb. were tested for in vivo antihypoxic activity using mice, with the EtOAc extract showing better activity.
Keywords: Hypericum japonicum Thunb.; 4; 6-Dimethyl-5-O-[á-L-rhamnopyranosyl- (1→6)-â-D-Glucopyranosyl] multifidol; Antihypoxic activity Hypericum japonicum Thunb.; 4; 6-Dimethyl-5-O-[á-L-rhamnopyranosyl- (1→6)-â-D-Glucopyranosyl] multifidol; Antihypoxic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Wang, X.W.; Mao, Y.; Wang, N.-L.; Yao, X.S. A New Phloroglucinol Diglycoside Derivative from Hypericum japonicum Thunb.. Molecules 2008, 13, 2796-2803.

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