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Molecules 2008, 13(11), 2796-2803; doi:10.3390/molecules13112796
Article

A New Phloroglucinol Diglycoside Derivative from Hypericum japonicum Thunb.

1,2
, 2
, 1,*  and 1,*
1 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, 103. Wenhua Road Shenhe District, Shenyang, Liaoning 110016, P.R. China 2 Shenzhen Institute for Drug Control, Shenzhen, Guangdong 518029, P.R. China
* Authors to whom correspondence should be addressed.
Received: 30 September 2008 / Revised: 27 October 2008 / Accepted: 4 November 2008 / Published: 7 November 2008
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Abstract

A new phloroglucinol diglycoside 1, together with eight known compounds, were isolated from Hypericum japonicum Thunb. The structure of the new compound 1 was determined by spectroscopic methods to be 4,6-dimethyl-5-O-[α-L-rhamnopyranosyl-(1→6)-α-D-glucopyranosyl] multifidol. Different solvent extracts of Hypericum japonicum Thunb. were tested for in vivo antihypoxic activity using mice, with the EtOAc extract showing better activity.
Keywords: Hypericum japonicum Thunb.; 4; 6-Dimethyl-5-O-[á-L-rhamnopyranosyl- (1→6)-â-D-Glucopyranosyl] multifidol; Antihypoxic activity Hypericum japonicum Thunb.; 4; 6-Dimethyl-5-O-[á-L-rhamnopyranosyl- (1→6)-â-D-Glucopyranosyl] multifidol; Antihypoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, X.W.; Mao, Y.; Wang, N.-L.; Yao, X.S. A New Phloroglucinol Diglycoside Derivative from Hypericum japonicum Thunb.. Molecules 2008, 13, 2796-2803.

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