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A New Phloroglucinol Diglycoside Derivative from Hypericum japonicum Thunb.
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, 103. Wenhua Road Shenhe District, Shenyang, Liaoning 110016, P.R. China
Shenzhen Institute for Drug Control, Shenzhen, Guangdong 518029, P.R. China
* Authors to whom correspondence should be addressed.
Received: 30 September 2008; in revised form: 27 October 2008 / Accepted: 4 November 2008 / Published: 7 November 2008
Abstract: A new phloroglucinol diglycoside 1, together with eight known compounds, were isolated from Hypericum japonicum Thunb. The structure of the new compound 1 was determined by spectroscopic methods to be 4,6-dimethyl-5-O-[α-L-rhamnopyranosyl-(1→6)-α-D-glucopyranosyl] multifidol. Different solvent extracts of Hypericum japonicum Thunb. were tested for in vivo antihypoxic activity using mice, with the EtOAc extract showing better activity.
Keywords: Hypericum japonicum Thunb.; 4; 6-Dimethyl-5-O-[á-L-rhamnopyranosyl- (1→6)-â-D-Glucopyranosyl] multifidol; Antihypoxic activity
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Cite This Article
MDPI and ACS Style
Wang, X.W.; Mao, Y.; Wang, N.-L.; Yao, X.S. A New Phloroglucinol Diglycoside Derivative from Hypericum japonicum Thunb.. Molecules 2008, 13, 2796-2803.
Wang XW, Mao Y, Wang N-L, Yao XS. A New Phloroglucinol Diglycoside Derivative from Hypericum japonicum Thunb.. Molecules. 2008; 13(11):2796-2803.
Wang, Xiao W.; Mao, Yu; Wang, Nai-Li; Yao, Xin S. 2008. "A New Phloroglucinol Diglycoside Derivative from Hypericum japonicum Thunb.." Molecules 13, no. 11: 2796-2803.