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• Wan, J
• Wang, C
• Sun, C
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• Wan, J
• Wang, C
• Sun, C
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• Wan, J
• Wang, C
• Sun, C

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Molecules 2008, 13(10), 2652-2658; doi:10.3390/molecules13102652

Communication

Diastereoselective Synthesis of Cyclopentanediols by InCl3/Al Mediated Intramolecular Pinacol Coupling Reaction in Aqueous Media

Yunhua Chen² , Jieping Wan¹ , Chunyan Wang¹  and Cuirong Sun^1,*

¹ Department of Chemistry, Zhejiang University, Hangzhou, 310027, P.R. China ² Zhejiang Hisun Pharm. Co. Ltd. Taizhou, 318000, P.R. China

* Author to whom correspondence should be addressed.

Received: 2 August 2008; in revised form: 14 October 2008 / Accepted: 15 October 2008 / Published: 27 October 2008

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Abstract: A “green” and practical intramolecular pinacol coupling reaction promoted by InCl₃/Al catalysts in aqueous media has been developed. Under mild conditions, a novel class of polysubstituted cyclopentane-1,2-diols have been obtained with excellent diastereoselectivity.

Keywords: Intramolecular; Pinacol coupling; Indium; Aluminium; Aqueous media

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