Molecules 2008, 13(10), 2557-2569; doi:10.3390/molecules13102557
Article

Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives

Hanan Georgey* email, Nagwa Abdel-Gawademail and Safinaz Abbasemail
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Eini Street, Cairo 11562, Egypt
* Author to whom correspondence should be addressed.
Received: 4 September 2008; in revised form: 18 September 2008 / Accepted: 15 October 2008 / Published: 16 October 2008
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Abstract: A number of 3-substituted-2-(substituted-phenoxymethyl) quinazolin-4(3H)-one derivatives 4a,b, 5a-c, 6, 7a-f, 8a-e and 9a,b have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1H-NMR, MS). A preliminary evaluation of the anticonvulsant activity of the prepared compounds has indicated that compounds 4b, 7b-f, 8a and 9b exhibit significant anticonvulsant activity, while compounds 6, 8b and 8d show mild to moderate activity.
Keywords: Quinazolin-4-(3H)-ones; piperazines; chloroacetamide; anticonvulsant activity

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MDPI and ACS Style

Georgey, H.; Abdel-Gawad, N.; Abbas, S. Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives. Molecules 2008, 13, 2557-2569.

AMA Style

Georgey H, Abdel-Gawad N, Abbas S. Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives. Molecules. 2008; 13(10):2557-2569.

Chicago/Turabian Style

Georgey, Hanan; Abdel-Gawad, Nagwa; Abbas, Safinaz. 2008. "Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives." Molecules 13, no. 10: 2557-2569.

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