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Molecules 2008, 13(10), 2557-2569; doi:10.3390/molecules13102557

Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives

* ,
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Eini Street, Cairo 11562, Egypt
* Author to whom correspondence should be addressed.
Received: 4 September 2008 / Revised: 18 September 2008 / Accepted: 15 October 2008 / Published: 16 October 2008
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A number of 3-substituted-2-(substituted-phenoxymethyl) quinazolin-4(3H)-one derivatives 4a,b, 5a-c, 6, 7a-f, 8a-e and 9a,b have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1H-NMR, MS). A preliminary evaluation of the anticonvulsant activity of the prepared compounds has indicated that compounds 4b, 7b-f, 8a and 9b exhibit significant anticonvulsant activity, while compounds 6, 8b and 8d show mild to moderate activity.
Keywords: Quinazolin-4-(3H)-ones; piperazines; chloroacetamide; anticonvulsant activity Quinazolin-4-(3H)-ones; piperazines; chloroacetamide; anticonvulsant activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Georgey, H.; Abdel-Gawad, N.; Abbas, S. Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives. Molecules 2008, 13, 2557-2569.

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