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Molecules 2008, 13(10), 2557-2569; doi:10.3390/molecules13102557

Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Eini Street, Cairo 11562, Egypt
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Received: 4 September 2008 / Revised: 18 September 2008 / Accepted: 15 October 2008 / Published: 16 October 2008
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Abstract

A number of 3-substituted-2-(substituted-phenoxymethyl) quinazolin-4(3H)-one derivatives 4a,b, 5a-c, 6, 7a-f, 8a-e and 9a,b have been synthesized. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1H-NMR, MS). A preliminary evaluation of the anticonvulsant activity of the prepared compounds has indicated that compounds 4b, 7b-f, 8a and 9b exhibit significant anticonvulsant activity, while compounds 6, 8b and 8d show mild to moderate activity.
Keywords: Quinazolin-4-(3H)-ones; piperazines; chloroacetamide; anticonvulsant activity Quinazolin-4-(3H)-ones; piperazines; chloroacetamide; anticonvulsant activity
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MDPI and ACS Style

Georgey, H.; Abdel-Gawad, N.; Abbas, S. Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives. Molecules 2008, 13, 2557-2569.

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