Molecules 2008, 13(1), 69-77; doi:10.3390/molecules13010069
Article

Synthesis and Antiplasmodial Activity of 3-Furyl and 3-Thienylquinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives

1, 2, 2, 1, 1, 1, 1, 1, 1,* email, 2 and 1
Received: 18 December 2007; Accepted: 11 January 2008 / Published: 17 January 2008
(This article belongs to the Special Issue ECSOC-11)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The aim of this study was to identify new compounds active againstPlasmodium falciparum based on our previous research carried out on 3-phenylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives. Twelve compounds weresynthesized and evaluated for antimalarial activity. Eight of them showed an IC50 less than 1 μMagainst the 3D7 strain. Derivative 1 demonstrated high potency (IC50= 0.63 μM) and goodselectivity (SI=10.35), thereby becoming a new lead-compound.
Keywords: Quinoxaline; N-oxides; malaria; antiplasmodial; P. falciparum.
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MDPI and ACS Style

Vicente, E.; Charnaud, S.; Bongard, E.; Villar, R.; Burguete, A.; Solano, B.; Ancizu, S.; Pérez-Silanes, S.; Aldana, I.; Vivas, L.; Monge, A. Synthesis and Antiplasmodial Activity of 3-Furyl and 3-Thienylquinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives. Molecules 2008, 13, 69-77.

AMA Style

Vicente E, Charnaud S, Bongard E, Villar R, Burguete A, Solano B, Ancizu S, Pérez-Silanes S, Aldana I, Vivas L, Monge A. Synthesis and Antiplasmodial Activity of 3-Furyl and 3-Thienylquinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives. Molecules. 2008; 13(1):69-77.

Chicago/Turabian Style

Vicente, Esther; Charnaud, Sarah; Bongard, Emily; Villar, Raquel; Burguete, Asunción; Solano, Beatriz; Ancizu, Saioa; Pérez-Silanes, Silvia; Aldana, Ignacio; Vivas, Livia; Monge, Antonio. 2008. "Synthesis and Antiplasmodial Activity of 3-Furyl and 3-Thienylquinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives." Molecules 13, no. 1: 69-77.


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