Molecules 2008, 13(1), 177-189; doi:10.3390/molecules13010177
Article

New Di-(β-chloroethyl)-α-amides on N-(meta-Acylaminobenzoyl)- D,L-aminoacid Supports with Antitumoral Activity

Valeriu Sunel 1 email, Marcel Popa 2 email, Jacques Desbrières 3 , Lenuta Profire 4,* email, Pintilie Otilia 1 email and Lionte Catalina 5
1 Department of Organic Chemistry and Biochemistry, Faculty of Chemistry, Al. I. Cuza University, Iasi, 11 B-dul Carol I, 700506, Romania 2 Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, Gh. Asachi Technical University, 71A B-dul Mangeron, Iasi, 700050, Romania 3 IPREM/EPCP, UMR 5254 CNRS, University of Pau et Pays de l’Adour, Hélioparc Pau Pyrénées 2, av. President Angout, 64053 Pau, France 4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gr. T. Popa Medicine and Pharmacy University, 16 Universitatii Street, 700115, Romania 5 Medical Clinic, Emergency Clinic Hospital, Faculty of Medicine, Gr. T. Popa Medicine and Pharmacy University, 16 Universitatii Street, 700115, Romania
* Author to whom correspondence should be addressed.
Received: 30 December 2007; in revised form: 23 January 2007 / Accepted: 23 January 2007 / Published: 28 January 2008
PDF Full-text Download PDF Full-Text [247 KB, uploaded 1 October 2008 09:18 CEST]
Abstract: In order to obtain new compounds with antitumoural action the N-(metaacylaminobenzoyl)-α-acylaminobenzoyl)-α-aminoacids 4-9 were prepared. Thesecompounds were subsequently converted into the corresponding δ2-oxazolin-5-ones 10-15,which in turn were submitted to a ring opening reaction with di-(β-chloroethyl)amine toafford the peptide supported N-mustards 16-21, which showed low toxicity and cytostaticactivity similar to that of sarcolisine against the Ehrlich ascite and Walker 253carcinosarcoma.
Keywords: N-(acylaminobenzoyl)-α-aminoacids; Δ2-oxazolin-5-ones; anticancer agents;

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Sunel, V.; Popa, M.; Desbrières, J.; Profire, L.; Otilia, P.; Catalina, L. New Di-(β-chloroethyl)-α-amides on N-(meta-Acylaminobenzoyl)- D,L-aminoacid Supports with Antitumoral Activity. Molecules 2008, 13, 177-189.

AMA Style

Sunel V, Popa M, Desbrières J, Profire L, Otilia P, Catalina L. New Di-(β-chloroethyl)-α-amides on N-(meta-Acylaminobenzoyl)- D,L-aminoacid Supports with Antitumoral Activity. Molecules. 2008; 13(1):177-189.

Chicago/Turabian Style

Sunel, Valeriu; Popa, Marcel; Desbrières, Jacques; Profire, Lenuta; Otilia, Pintilie; Catalina, Lionte. 2008. "New Di-(β-chloroethyl)-α-amides on N-(meta-Acylaminobenzoyl)- D,L-aminoacid Supports with Antitumoral Activity." Molecules 13, no. 1: 177-189.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert