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Molecules 2008, 13(1), 170-176; doi:10.3390/molecules13010170

Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazine

1
Chemistry Department, Faculty of Science, Islamic University of Gaza, P. O. Box 108, Gaza, Palestine
2
Chemistry Department, Faculty of Science, University of Jordan, Amman, Jordan
*
Author to whom correspondence should be addressed.
Received: 9 January 2008 / Revised: 22 January 2008 / Accepted: 22 January 2008 / Published: 28 January 2008
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Abstract

The reaction of nitrilimine 6a with ethyl pyridine-2-acetate (7) gave thecorresponding pyrrolo[1,2-a]pyridine 8, while the reaction of 6b containing an estermoiety afforded the acyclic adduct 9. The reaction of 6a with 2-aminopyrimidine (10)gave the novel unexpected pyrimido[2,1-d]1,2,3,5-tetrazine 11. Acyclic adducts 16 and17 were obtained from the reaction of 6b with 2-cyanomethylbenzimidazole (14) and 2-aminobenzimidazole (15), respectively. View Full-Text
Keywords: Nitrilimines; ethyl pyridine-2-acetate; pyrrolo[1; 2-a]pyridine; 2-aminopyrimidine; Nitrilimines; ethyl pyridine-2-acetate; pyrrolo[1; 2-a]pyridine; 2-aminopyrimidine;
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Awadallah, A.M.; Zahra, J.A. Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazine. Molecules 2008, 13, 170-176.

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