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Molecules 2008, 13(1), 170-176; doi:10.3390/molecules13010170
Article

Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazine

1,*  and 2
Received: 9 January 2008; in revised form: 22 January 2008 / Accepted: 22 January 2008 / Published: 28 January 2008
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Abstract: The reaction of nitrilimine 6a with ethyl pyridine-2-acetate (7) gave thecorresponding pyrrolo[1,2-a]pyridine 8, while the reaction of 6b containing an estermoiety afforded the acyclic adduct 9. The reaction of 6a with 2-aminopyrimidine (10)gave the novel unexpected pyrimido[2,1-d]1,2,3,5-tetrazine 11. Acyclic adducts 16 and17 were obtained from the reaction of 6b with 2-cyanomethylbenzimidazole (14) and 2-aminobenzimidazole (15), respectively.
Keywords: Nitrilimines; ethyl pyridine-2-acetate; pyrrolo[1; 2-a]pyridine; 2-aminopyrimidine; Nitrilimines; ethyl pyridine-2-acetate; pyrrolo[1; 2-a]pyridine; 2-aminopyrimidine;
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MDPI and ACS Style

Awadallah, A.M.; Zahra, J.A. Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazine. Molecules 2008, 13, 170-176.

AMA Style

Awadallah AM, Zahra JA. Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazine. Molecules. 2008; 13(1):170-176.

Chicago/Turabian Style

Awadallah, Adel M.; Zahra, Jalal A. 2008. "Reaction of Nitrilimines with 2-Substituted Aza-heterocycles. Synthesis of Pyrrolo[1,2-a]pyridine and Pyrimido[2,1-d]1,2,3,5- tetrazine." Molecules 13, no. 1: 170-176.


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