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Molecules 2008, 13(1), 11-30; doi:10.3390/molecules13010011
Article

Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents

1, 1, 2, 1, 1 and 1,*
1 University of Ljubljana, Faculty of Pharmacy, Aškerčeva 7, 1000 Ljubljana, Slovenia 2 Enveloppes Bactériennes et Antibiotiques, IBBMC, UMR 8619 CNRS, Univ Paris-Sud, 91405 Orsay, France 3 “Jožef Stefan” Institute, Jamova 39, 1000 Ljubljana, Slovenia
* Author to whom correspondence should be addressed.
Received: 19 November 2007 / Revised: 23 December 2007 / Accepted: 23 December 2007 / Published: 11 January 2008
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Abstract

A series of novel N-benzylidenesulfonohydrazide compounds were designedand synthesized as inhibitors of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) andUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) from E. coli, involved inthe biosynthesis of bacterial cell-walls. Some compounds possessed inhibitory activityagainst both enzymes with IC50 values as low as 30 μM. In addition, a new, one-potsynthesis of amidobenzaldehydes is reported.
Keywords: MurC; MurD; amidobenzaldehyde; inhibitors; antibacterial; hydrazide. MurC; MurD; amidobenzaldehyde; inhibitors; antibacterial; hydrazide.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Frlan, R.; Kovač, A.; Blanot, D.; Gobec, S.; Pečar, S.; Obreza, A. Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents. Molecules 2008, 13, 11-30.

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