Next Article in Journal
Efficacy of DA-7218, a New Oxazolidinone Prodrug, in the Treatment of Experimental Actinomycetoma Produced by Nocardia brasiliensis
Previous Article in Journal
NMR Spectra of Sparteine N1-oxide and α-Isosparteine N-oxide
Molecules 2008, 13(1), 11-30; doi:10.3390/molecules13010011
Article

Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents

1, 1, 2, 1, 1 and 1,*
1 University of Ljubljana, Faculty of Pharmacy, Aškerčeva 7, 1000 Ljubljana, Slovenia 2 Enveloppes Bactériennes et Antibiotiques, IBBMC, UMR 8619 CNRS, Univ Paris-Sud, 91405 Orsay, France 3 “Jožef Stefan” Institute, Jamova 39, 1000 Ljubljana, Slovenia
* Author to whom correspondence should be addressed.
Received: 19 November 2007 / Revised: 23 December 2007 / Accepted: 23 December 2007 / Published: 11 January 2008
Download PDF [155 KB, uploaded 18 June 2014]

Abstract

A series of novel N-benzylidenesulfonohydrazide compounds were designedand synthesized as inhibitors of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) andUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) from E. coli, involved inthe biosynthesis of bacterial cell-walls. Some compounds possessed inhibitory activityagainst both enzymes with IC50 values as low as 30 μM. In addition, a new, one-potsynthesis of amidobenzaldehydes is reported.
Keywords: MurC; MurD; amidobenzaldehyde; inhibitors; antibacterial; hydrazide. MurC; MurD; amidobenzaldehyde; inhibitors; antibacterial; hydrazide.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Frlan, R.; Kovač, A.; Blanot, D.; Gobec, S.; Pečar, S.; Obreza, A. Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents. Molecules 2008, 13, 11-30.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert