ࡱ > Z \ Y y bjbjEE N, ' ' c ! ! ! 5 5 5 8 m \ 5 L t : - - - `# `# `# L L L L L L L YN P L ! `# \# `# `# `# L - - / L % % % `# 8 - ! - L % `# L % % xG K - zH 5 % 4K ^ tL L 0 L K ^ Q % Q K Q ! K `# `# % `# `# `# `# `# L L % . `# `# `# L `# `# `# `# Q `# `# `# `# `# `# `# `# `# : Molecules 2007, 12, 2160
molecules
ISSN 1420-3049
2007 by MDPI HYPERLINK "http://www.mdpi.org/molecules"www.mdpi.org/molecules
Editorial Note
Withdrawn Paper: Li, M. D.; Zheng, Y. G.; Ji, M. Synthesis of Gefitinib from Methyl 3-Hydroxy-4-methoxybenzoate. Molecules 2007, 12, 673-678
Received: 8 September 2007 / Published: 10 September 2007
It has been brought to our attention by an alert medicinal chemist from the P. R. China that Scheme 3 and the Experimental section of this paper [1] had been copied from an earlier paper by Gong et al. [2], published in Chinese [3]. In addition, the m.p. of 119-120C given for the final product Gefitinib (7) was also copied from an earlier publication [4], and later shown to be wrong [5]. The first listed author has subsequently provided us with another different melting point for Gefitinib (212-214C) and informed us that the correct melting points for the intermediates methyl 5-(3-chloropropoxy)-4-methoxy-2-nitrobenzoate (18) and 6-(3-chloropropoxy)-4-chloro-7-methoxy-quinazoline (21) should be revised to 79-81C and 128-130C, respectively. In light of these serious factual errors and the apparent plagiarism, the Editorial Team and the Publisher have determined that the paper should be declared Withdrawn. We apologize to our readership for any inconvenience this may cause.
Dr. Derek J. McPhee, Editor-in-Chief, Molecules
Dr. Shu Kun Lin, Publisher, MDPI
References and Notes
1. Li, M. D.; Zheng, Y. G.; Ji, M. Synthesis of Gefitinib from Methyl 3-Hydroxy-4-methoxy-benzoate. Molecules 2007, 12, 673-678.
2. Dr. Ping Gong, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, Liaoning, P. R. China; Fax: (+86) 24-23986426/23882925, Phone: (+86) 24-23986426, E-mail: gongpinggp@126.com.
3. Yuan, L.; Hao, J.-H.; Zhang, Y.; Wang, Y.-Y.; Wang, H.; Chen.; J.-Y.; Gong, P. Synthesis of 4-(3-chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline (ZD1839). Chin. J. Med. Chem. 2005, 15, 39-41.
4. Gibson, K.H. Quinazoline derivatives. WO9633980, 1996; p. 24.
5. Recently a melting point of 194-198 C was reported for Gefitinib; Gilday, J. P.; David, M. Process for the preparation of 4-(3-chloro-4-fluoroanilino)-7-methoxy-6-(3-morpholino-propoxy)quinazoline. WO2004024703, 2006; p. 12.
2007 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
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Molecules 2007, 12
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