An Efficient and Rapid Synthetic Route to Biologically Interesting Pyranochalcone Natural Products

doi:10.3390/12071420

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Molecules 2007, 12(7), 1420-1429; doi:10.3390/12071420

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An Efficient and Rapid Synthetic Route to Biologically Interesting Pyranochalcone Natural Products

Yong Rok Lee* , Xue Wang and Likai Xia

School of Chemical Engineering and Technology, Yeungnam University, Gyeongsan 712-749, Korea

* Author to whom correspondence should be addressed.

Received: 29 June 2007; in revised form: 10 July 2007 / Accepted: 10 July 2007 / Published: 12 July 2007

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Abstract: An efficient and concise total synthesis of naturally occurring pyranochalcones was achieved from readily available 2,4-dihydroxyacetophenone and 2,4-dihydroxy-6- methoxyacetophenone. The key steps in the synthetic strategy were ethylenediamine diacetate-catalyzed benzopyran formation and aldol reactions.

Keywords: Ethylenediamine diacetate;Pyranyl ring formation;Pyranochalcone natural products;Aldol reaction

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MDPI and ACS Style

Lee, Y.R.; Wang, X.; Xia, L. An Efficient and Rapid Synthetic Route to Biologically Interesting Pyranochalcone Natural Products. Molecules 2007, 12, 1420-1429.

AMA Style

Lee YR, Wang X, Xia L. An Efficient and Rapid Synthetic Route to Biologically Interesting Pyranochalcone Natural Products. Molecules. 2007; 12(7):1420-1429.

Chicago/Turabian Style

Lee, Yong R.; Wang, Xue; Xia, Likai. 2007. "An Efficient and Rapid Synthetic Route to Biologically Interesting Pyranochalcone Natural Products." Molecules 12, no. 7: 1420-1429.

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