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Molecules 2007, 12(7), 1341-1351; doi:10.3390/12071341
Article

Synthesis of 4-Aryl Substituted 3,4-Dihydropyrimidinones Using Silica-chloride Under Solvent Free Conditions

,  and *
Discovery Center, Process Technology Development Division, Defence R and D Establishment, Jhansi Road, Gwalior 474002 (MP) India
* Author to whom correspondence should be addressed.
Received: 21 May 2007 / Revised: 20 June 2007 / Accepted: 2 July 2007 / Published: 9 July 2007
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Abstract

This paper describes an improved procedure for the efficient and facile synthesis of 4-aryl substituted 3, 4-dihydropyrimidinones under mild reaction conditions with excellent yields using inexpensive silica chloride under solvent free conditions.
Keywords: Biginelli reaction; Dihydropyrimidinones; silica chloride; solvent free. Biginelli reaction; Dihydropyrimidinones; silica chloride; solvent free.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Karade, H.N.; Sathe, M.; Kaushik, M.P. Synthesis of 4-Aryl Substituted 3,4-Dihydropyrimidinones Using Silica-chloride Under Solvent Free Conditions. Molecules 2007, 12, 1341-1351.

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