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Molecules 2007, 12(7), 1341-1351; doi:10.3390/12071341
Article

Synthesis of 4-Aryl Substituted 3,4-Dihydropyrimidinones Using Silica-chloride Under Solvent Free Conditions

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Received: 21 May 2007 / Revised: 20 June 2007 / Accepted: 2 July 2007 / Published: 9 July 2007
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Abstract

This paper describes an improved procedure for the efficient and facile synthesis of 4-aryl substituted 3, 4-dihydropyrimidinones under mild reaction conditions with excellent yields using inexpensive silica chloride under solvent free conditions.
Keywords: Biginelli reaction; Dihydropyrimidinones; silica chloride; solvent free. Biginelli reaction; Dihydropyrimidinones; silica chloride; solvent free.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Karade, H.N.; Sathe, M.; Kaushik, M.P. Synthesis of 4-Aryl Substituted 3,4-Dihydropyrimidinones Using Silica-chloride Under Solvent Free Conditions. Molecules 2007, 12, 1341-1351.

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