Synthesis of 4-Aryl Substituted 3,4-Dihydropyrimidinones Using Silica-chloride Under Solvent Free Conditions

doi:10.3390/12071341

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Molecules 2007, 12(7), 1341-1351; doi:10.3390/12071341

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Synthesis of 4-Aryl Substituted 3,4-Dihydropyrimidinones Using Silica-chloride Under Solvent Free Conditions

Hitendra N Karade, Manisha Sathe and M P Kaushik*

Discovery Center, Process Technology Development Division, Defence R and D Establishment, Jhansi Road, Gwalior 474002 (MP) India

* Author to whom correspondence should be addressed.

Received: 21 May 2007; in revised form: 20 June 2007 / Accepted: 2 July 2007 / Published: 9 July 2007

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Abstract: This paper describes an improved procedure for the efficient and facile synthesis of 4-aryl substituted 3, 4-dihydropyrimidinones under mild reaction conditions with excellent yields using inexpensive silica chloride under solvent free conditions.

Keywords: Biginelli reaction; Dihydropyrimidinones; silica chloride; solvent free.

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MDPI and ACS Style

Karade, H.N.; Sathe, M.; Kaushik, M.P. Synthesis of 4-Aryl Substituted 3,4-Dihydropyrimidinones Using Silica-chloride Under Solvent Free Conditions. Molecules 2007, 12, 1341-1351.

AMA Style

Karade HN, Sathe M, Kaushik MP. Synthesis of 4-Aryl Substituted 3,4-Dihydropyrimidinones Using Silica-chloride Under Solvent Free Conditions. Molecules. 2007; 12(7):1341-1351.

Chicago/Turabian Style

Karade, Hitendra N.; Sathe, Manisha; Kaushik, M P. 2007. "Synthesis of 4-Aryl Substituted 3,4-Dihydropyrimidinones Using Silica-chloride Under Solvent Free Conditions." Molecules 12, no. 7: 1341-1351.

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