A Novel and Efficient Synthesis of N,N-Dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido Oximes - Potential Marine Fish Toxin Analogues. Part 1

doi:10.3390/12071334

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Molecules 2007, 12(7), 1334-1340; doi:10.3390/12071334

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A Novel and Efficient Synthesis of N,N-Dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido Oximes - Potential Marine Fish Toxin Analogues. Part 1

Rajesh Kumar, Arvind K. Gupta and Mahabir P. Kaushik *

Process Technology Development Division, Defence R and D Establishment, Jhansi Road, Gwalior 474002 (MP) India

* Author to whom correspondence should be addressed.

Received: 16 April 2007; in revised form: 16 May 2007 / Accepted: 16 July 2007 / Published: 9 July 2007

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Abstract: A novel and efficient method for the synthesis of N,N-dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido oximes (4) using activated silica as dehydrating agent has been developed. The reaction involves the condensation of substituted diacetyl monoxime and N,N-dialkylaminoisopropyl-phosphono hydrazide or O-alkylisopropylphosphono hydrazides and gave the corresponding analogues of a naturally occurring fish toxin in excellent yields under mild conditions.

Keywords: Hydrazides; diacetyl monoxime; marine fish toxin; phosphonohydrazido oxime

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MDPI and ACS Style

Kumar, R.; Gupta, A.K.; Kaushik, M.P. A Novel and Efficient Synthesis of N,N-Dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido Oximes - Potential Marine Fish Toxin Analogues. Part 1. Molecules 2007, 12, 1334-1340.

AMA Style

Kumar R., Gupta A.K., Kaushik M.P. A Novel and Efficient Synthesis of N,N-Dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido Oximes - Potential Marine Fish Toxin Analogues. Part 1. Molecules. 2007; 12(7):1334-1340.

Chicago/Turabian Style

Kumar, Rajesh; Gupta, Arvind K.; Kaushik, Mahabir P. 2007. "A Novel and Efficient Synthesis of N,N-Dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido Oximes - Potential Marine Fish Toxin Analogues. Part 1." Molecules 12, no. 7: 1334-1340.

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