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Molecules 2007, 12(6), 1202-1209; doi:10.3390/12061202
Article

Synthesis and Biological Evaluation of Some Novel Schiff’s Bases from 1,2,4-Triazole

1
,
1, 1
 and
1,*
1 College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, P .R. China 2 Wenzhou Medical College, Wenzhou 325035, P. R. China
* Author to whom correspondence should be addressed.
Received: 7 April 2007 / Revised: 3 June 2007 / Accepted: 4 June 2007 / Published: 5 July 2007
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Abstract

We have synthesized a number of novel Schiff’s bases from 4-amino-3-(D-glucoheptonic-hexitol-1-yl)-1H-1,2,4-triazole-5-thione. By attaching D-glucoheptonic-hexitol-1-yl residues to 1,2,4-triazole at the 3-position, the solubility of the title compounds has been improved greatly. All the products have been characterized by elemental analysis, IR, 1H-NMR, 13C-NMR and MS. The plant-growth regulating effects of the title compounds were examined. From the biological activity results, we found that most compounds showed weak to moderate activities.
Keywords: Schiff's bases; glucoheptonic acid residue; 4-amino-3-(D-glucoheptonic-hexitol-1-yl)-1H-1; 2; 4-triazole-5-thione; plant growth regulation Schiff's bases; glucoheptonic acid residue; 4-amino-3-(D-glucoheptonic-hexitol-1-yl)-1H-1; 2; 4-triazole-5-thione; plant growth regulation
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ye, X.-X.; Chen, Z.-F.; Zhang, A.-J.; Zhang, L.-X. Synthesis and Biological Evaluation of Some Novel Schiff’s Bases from 1,2,4-Triazole. Molecules 2007, 12, 1202-1209.

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