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Synthesis and Biological Evaluation of Some Novel Schiff’s Bases from 1,2,4-Triazole
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, P .R. China
Wenzhou Medical College, Wenzhou 325035, P. R. China
* Author to whom correspondence should be addressed.
Received: 7 April 2007; in revised form: 3 June 2007 / Accepted: 4 June 2007 / Published: 5 July 2007
Abstract: We have synthesized a number of novel Schiff’s bases from 4-amino-3-(D-glucoheptonic-hexitol-1-yl)-1H-1,2,4-triazole-5-thione. By attaching D-glucoheptonic-hexitol-1-yl residues to 1,2,4-triazole at the 3-position, the solubility of the title compounds has been improved greatly. All the products have been characterized by elemental analysis, IR, 1H-NMR, 13C-NMR and MS. The plant-growth regulating effects of the title compounds were examined. From the biological activity results, we found that most compounds showed weak to moderate activities.
Keywords: Schiff's bases; glucoheptonic acid residue; 4-amino-3-(D-glucoheptonic-hexitol-1-yl)-1H-1; 2; 4-triazole-5-thione; plant growth regulation
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MDPI and ACS Style
Ye, X.-X.; Chen, Z.-F.; Zhang, A.-J.; Zhang, L.-X. Synthesis and Biological Evaluation of Some Novel Schiff’s Bases from 1,2,4-Triazole. Molecules 2007, 12, 1202-1209.
Ye X-X, Chen Z-F, Zhang A-J, Zhang L-X. Synthesis and Biological Evaluation of Some Novel Schiff’s Bases from 1,2,4-Triazole. Molecules. 2007; 12(6):1202-1209.
Ye, Xiao-Xia; Chen, Zhen-Fei; Zhang, An-Jiang; Zhang, Li-Xue. 2007. "Synthesis and Biological Evaluation of Some Novel Schiff’s Bases from 1,2,4-Triazole." Molecules 12, no. 6: 1202-1209.