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Communication

A New Type of NADH Model Compound: Synthesis and Enantioselective Reduction of Benzoylformates to the Corresponding Mandelates

1
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, , P.R. China
2
Beijing Insititute of Technology, Beijing 100081, P. R. China
*
Author to whom correspondence should be addressed.
Molecules 2007, 12(5), 979-987; https://doi.org/10.3390/12050979
Submission received: 23 March 2007 / Revised: 17 April 2007 / Accepted: 19 April 2007 / Published: 11 May 2007

Abstract

:
A new type of NADH model compound with good reactivity and enantioselectivity has been synthesized in good yields by an efficient and convenient synthetic method. The structures of these model compounds were confirmed by 1H- and 13C-NMR and MS.

Introduction

Since Ohno and coworkers [1] reported the first NADH model compound, a large number of such mimics have been developed [2]. In particular, chiral NADH model compounds have been extensively studied with the aim of developing new enantioselective reducing agents [2]. Generally, highly stereoselective chiral NADH models have been designed by incorporating remote sterically-demanding side chains [3] or a substituent at the reaction centre: the C4 position of the dihydropyridine ring [4]. However, the former approach implies a significant modification of the dihydropyridine ring and the latter one resulted in a loss of chirality at the C4 position during the course of the model reaction. Recently, several NADH models with specific conformations which could steroselectively reduce pyruvate mimics were reported [5], and a few such models have been studied so far. Herein we report a novel chiral NADH model compounds 1a,b, possessing a specific C2-symmetric conformation.
Figure 1. The new NADH model compounds 1a,b.
Figure 1. The new NADH model compounds 1a,b.
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In our model compounds 1a,b four chiral carbon centers were introduced by the presence of (1R,2R)-diaminocyclohexane [6]. Two identical pyridine-3,5-dicarbonyl units were connected by two identical (1R,2R)-diaminocyclohexane units into a large ring. The C2-symmetric structure has the following advantages: (i) we can take advantage of an efficient bi-directional synthetic method to prepare 1a,b; (ii) it simplified the analysis of the reduction reactions using our model compounds 1a,b.

Results and Discussion

Generally, the single-protection method was used to synthesize macrocyclic compounds such as our models 1a,b (Scheme 1). One of amino groups of (1R,2R)-diaminocyclohexane was protected and the resulting compound 6 was reacted with pyridine-3,5-dicarbonyl dichloride to obtain compound 7. After deprotection of 7, the resulting amide 8 was converted to macrocyclic compound 4 by treatment with another portion of pyridine-3,5-dicarbonyl dichloride. However, this traditional method suffered from low yields and a long synthetic route. Herein, we would like to report a novel practical and efficient method as outlined in Scheme 2.
Although the pentafluorophenoxy is a good leaving group, bis(pentafluorophenyl)pyridine-3,5-dicarboxylate (3) is not so active as pyridine-3,5-dicarbonyl dichloride in the reaction with (1R,2R)-diaminocyclohexane. As a result, the key intermediate 4 was obtained conveniently in only one step from (1R,2R)-diaminocyclohexane, avoiding the complicated single-protected method. When an appropriate halide was added to a DMF solution of 4 and the resulting reaction mixture was heated at 80 ºC ~90 ºC for 12 h, then 5a,b were obtained. Crude 5a,b, used directly without further purification, was reduced by sodium dithionite to afford crude compounds 1a,b. After separation on Sephadex LH-20 with methanol as the eluent, pure model compounds 1a,b were obtained.
Scheme 1. Single-protection route to the key intermediate 4.
Scheme 1. Single-protection route to the key intermediate 4.
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Scheme 2. Preparation of NADH model compound 1.
Scheme 2. Preparation of NADH model compound 1.
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Reagents and conditions: a) pentafluorophenol, DMF, RT, 6 h, 92%; b) (1R,2R)-diamino-cyclohexane, THF, RT, 4 h, 62%; c) 5a: CH3I, 80 ºC ~90 ºC, 12 h, 72%; 5b: BrCH2Ph, 80 ºC ~90 ºC, 12 h, 64%; d) Na2S2O4, Na2CO3, H2O, 12 h, 1a: 71%, 1b: 41%
The C2-symmetric NADH models 1a,b could enantioselectivly reduce the pyruvate mimic methyl benzoylformate in acetonitrile in the presence of magnesium perchlorate (Scheme 3). The results summarized in Table 1 shows that NADH models 1a and 1b are similar as reducing agents. The resulting reduction products were the same enantiomer (R-mandelate) and they dispalyed similar enantiomeric excess values, so we believe that the reductibility and the enantioselectivity of model compounds 1a,b is related to their specific C2-symmetric conformation, rather than the substituent at the N1 position of the dihydropyridine rings.
Scheme 3. Asymmetric reduction of methyl benzoylformate with 1.
Scheme 3. Asymmetric reduction of methyl benzoylformate with 1.
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Table 1. Asymmetric reduction of methyl benzoylformate with 1.
Table 1. Asymmetric reduction of methyl benzoylformate with 1.
EntryT (°C) t9
Ee (%)aConfig.Yield (%)b
1aRT 3 d 68R 98
1bRT3 d 70R 96
a Determined by HPLC, see Experimental; b isolated yields.

Conclusions

In summary, a new type of NADH model compound with good reactivity and enantioselectivity has been synthesized in good yields by an efficient and convenient synthetic method.

Experimental Section

General

All starting materials were commercially available. DMF was dried with CaSO4 and distilled under reduced pressure. THF was distilled from CaH2. Melting points were measured on an X-4 digital microscope melting point apparatus (Beijing Tech Instrument Co., Ltd.). IR spectra (KBr disks) were recorded on a Perkin-Elmer Nicol FT-50X spectrometer. 1H-NMR and 13C-NMR were recorded on Bruker AC-300 FT or AV-400 FT instruments. The chemical shifts are reported in parts per million (ppm) downfield from internal tetramethylsilane (TMS). Electron impact MS spectra were obtained on a JEOL JMS-HX 100 instrument. High resolution mass spectra (HRMS) were measured in negative ion mode by Electrospray (ESI) on APEX-Qe 94 instrument. Chiralcel OD-H columns were purchased from Daicel Chemical Industries. Column chromatography was carried with silica gel (200-300 mesh), and HF254 silica gel for TLC was obtained from Qingdao Marine Chemistry Co. Ltd., Qingdao, China. Sephadex LH-20 (18-110 μm) was provided by H&E Co., Ltd.

bis(Pentafluorophenyl) pyridine-3,5-dicarboxylate (3)

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) (6.4 g, 33.2 mmol) was added to a solution of pyridine-3,5-dicarboxylic acid (2.8 g, 16.8 mmol) and pentafluorophenol (6.2 g, 33.2 mmol) in 150 mL of dry DMF. The resulting solution was stirred at room temperature for 6 h, water (200 mL) was added and a white precipitate formed. The product was collected by filtration and purified by flash column chromatography (silica gel, eluent CH2Cl2) to give compound 3 as a white solid (7.80 g, 93 %); m.p. 154~157 °C; 1H-NMR (300 MHz, CDCl3): δ=9.20 (s, 1H; pyr-4-CH), 9.68 ppm (s, 2H; pyr-2,6-CH); IR (KBr): v=3061, 2670, 2465, 1773, 1655, 1602, 1516, 1471, 1430, 1321, 1294, 1223, 1154, 1095, 996, 731 cm-1; EI-MS m/z (%): 316 (100), 260 (23.8), 183 (6.6), 105 (10.8).

(4R,9R,19R,24R)-3,10,14,18,25,29-Hexaazapentacyclo[25.3.1.112,16.04,9.019,24]dotriacontane-1(31),12 (32),13,15,27,29-hexaene-2,11,17,26-tetrone (4)

A solution of (1R,2R)-diaminocyclohexane (1.1 g, 9.6 mmol) in tetrahydrofuran (30 mL) was added to a solution of bis(pentafluorophenyl)pyridine-3,5-dicarboxylate (5.0 g, 10.0 mmol) in tetra-hydrofuran at 0 ºC (ice bath). Upon complete addition and then the solution was stirred at room temperature for 3 h. The solvent was removed to give the crude product. The product was purified by column chromatography (eluent: 30 % ethyl acetate-hexane) to give 4 as a white solid (1.5 g, yield 62 %); 1H- NMR (400 MHz, (CD3)2SO): δ=1.25-1.34 (m, 4H; CHH’CH2CHNH), 1.48-1.50 (m, 4H; CHH’CH2CHN-H), 1.71-1.73 (m, 4H; CHH’CHNH), 1.84-1.91 (m, 4H; CHH’CHNH), 3.94-3.99 (m, 4H; CHNH), 8.38 (s, 2H; pyr-4-CH), 8.57 (d, J=7.76, 4H; NH), 8.92 ppm (s, 4H; pyr-2,6-CH); 13C-NMR (100 MHz, (CD3)2SO): δ=24.9 (CH2CH2CHNH), 31.5 (CH2CHNH), 53.5 (CHNH), 130.3 (pyr-3,5-C), 134.8 (pyr-4-CH), 150.1 (pyr-2,6-CH), 165.0, 165.1 ppm (C=O); ESI-MS m/z=491.4 [M+H]+.

(4R,9R,19R,24R)-14,29-Dimethyl-3,10,14,18,25,29-hexaazapentacyclo[25.3.1.112,16.04,9.019,24]-dotria-conane-1(31),12(32),13,15,27,29-hexaene-2,11,17,26-tetrone iodide (5a)

Methyl iodide (5 mL) was added to a dry DMF (5 mL) solution of compound 4 (1.0 g, 4.1 mmol). The mixture was stirred under nitrogen at 80 ºC ~90 ºC for 12 h, then cooled and ether was added. The precipitate formed was collected by filtration and washed with ether to give the crude product 5a as a yellow solid (1.1 g, yield 72 %), which can be used without further purification.

(4R,9R,19R,24R)-14,29-Dibenzyl-3,10,14,18,25,29-hexaazapentacyclo[25.3.1.112,16.04,9.019,24]dotria-contane-1(31),12(32),13,15,27,29-hexaene-2,11,17,26-tetrone bromide (5b)

This preparation was carried out in a similar fashion to that of 5a, and the product was obtained as a yellow solid (1.1 g, yield 64 %).

(4R,9R,19R,24R)-14,29-Dimethyl-3,10,14,18,25,29-hexaazapentacyclo[25.3.1.112,16.04,9.019,24]dotria-contane-1,12,15,27-tetraene-2,11,17,26-tetrone (1a)

An aqueous solution (20 mL) of sodium dithionite (1.8 g, 10.3 mmol) and sodium carbonate (0.68 g, 6.5 mmol) was added dropwise at room temperature under nitrogen to an aqueous solution (10 mL) of compound 5 (0.5 g, 1.3 mmol). The mixture was left to stir over night at room temperature, during which time a yellow precipitate formed. The product was collected by filtration and purified by gel chromatography (Sephadex LH-20, eluent CH3OH) to give 1a as a yellow solid (0.24 g, yield 71 %); 1H-NMR (400 MHz, (CD3)2SO): δ=1.23-1.25 (m, 8H; CH2CH2CHNH), 1.66 (m, 4H; CHH’CHNH), 1.88 (m, 4H; CHH’CHNH), 2.90 (s, 4H; pyr-4-CH), 3.03 (s, 6H; CH3N), 3.54 (m, 4H; CHNH), 6.80 (s, 4H; pyr-2,6-CH), 7.27-7.28 ppm (m, 4H; NH); 13C-NMR (100 MHz, (CD3)2SO): δ=21.5 (CH2CH2CHNH), 24.6 (CH2CHNH), 31.8 (CH3N), 40.4 (pyr-4-CH2), 53.9 (CHNH), 104.1 (pyr-3,5-C), 136.6 (pyr-2,6-CH), 167.1 ppm (C=O); ESI-MS m/z=523.5 [M+H]+, 545.5 [M+Na]+.

(4R,9R,19R,24R)-14,29-Dibenzyl-3,10,14,18,25,29-hexaazapentacyclo[25.3.1.112,16.04,9.019,24]dotria-contane-1,12,15,27-tetraene -2,11,17,26-tetrone (1b)

This preparation was carried out in a similar fashion to that of 6a. The product was obtained as a yellow solid (0.17g, yield 41 %); 1H-NMR (400 MHz, (CD3)2SO): δ=1.24-1.29 (m, 8H; CH2CH2CHNH), 1.65 (m, 4H; CHH’CHNH), 1.88-1.90 (m, 4H; CHH’CHNH), 2.95 (s, 4H; pyr-4-CH), 3.54 (m, 4H; CHNH), 4.42 (d, J=15.66, 2H; ArCHH’), 4.58 (d, J=15.66, 2H; ArCHH’), 6.92 (s, 4H; pyr-2,6-CH), 7.27 (m, 4H; NH), 7.29-7.39 ppm (m, 10H; C6H5); 13C-NMR (100 MHz, (CD3)2SO): δ=21.9 (CH2CH2CHNH), 24.7 (CH2CHNH), 31.8 (pyr-4-CH2), 54.0 (CHNH), 56.4 (ArCH2), 104.8 (pyr-3,5-C), 127.4 (Ar-4-CH), 127.7 (Ar-2,6-CH), 128.9 (Ar-3,5-CH) 138.0 (Ar-1-C) 167.2 ppm (C=O); HR-MS(ESI) m/z=[M-H]- calcd. 673.35078, found 673.34907.

General Procedure for the asymmetric reduction of methyl benzoylformate with NADH model compounds 1a-b [2c]

The NADH model 1a-b (1 mmol), methyl benzoylformate (2 mmol) and magnesium perchlorate (2 mmol) were dissolved in acetonitrile (5 mL). The resulting solution was stirred in the dark under nitrogen at room temperature for 3 days. Water (0.5 mL) was then added and the product extracted with ether. The organic phase was dried and the solvent evaporated. The crude methyl mandelate was purified by chromatography, using 1:5 ethyl acetate/petroleum ether as eluent, to give a white solid. Product identity and enantiomeric excess were determined by HPLC analysis using a Chiracel OD-H column (0.46 cm I.D. x 25 cm L). Chromatographic conditions: injection: 10 μL; eluent: n-hexane/2-propanol = 85:15; flow rate: 1.0 mL/min; temperature: 35 °C. For 1a (Figure 2): UV detection: λ= 220 nm; tR = 5.819 min [(S)-enantiomer] and 8.495 min [(R)-enantiomer]. For 1b (Figure 3): UV detection: λ= 220 nm; tR = 5.814 min [(S)-enantiomer] and 8.464 min [(R)-enantiomer].
Figure 2. Resolution of methyl mandelate produced with 1a.
Figure 2. Resolution of methyl mandelate produced with 1a.
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Figure 3. Resolution of methyl mandelate produced with 1b.
Figure 3. Resolution of methyl mandelate produced with 1b.
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Acknowledgments

Support for this research was provided by the Nature Science Foundation of China (grants 20472090 and 10576034).

References and Notes

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  • Sample Availability: Samples of the compounds described in this paper are available from the authors.

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MDPI and ACS Style

Zhao, J.; Wang, N.-X.; Wang, W.-W.; Liu, Y.-H.; Li, L.; Wang, G.-X.; Yu, J.-L.; Tang, X.-L. A New Type of NADH Model Compound: Synthesis and Enantioselective Reduction of Benzoylformates to the Corresponding Mandelates. Molecules 2007, 12, 979-987. https://doi.org/10.3390/12050979

AMA Style

Zhao J, Wang N-X, Wang W-W, Liu Y-H, Li L, Wang G-X, Yu J-L, Tang X-L. A New Type of NADH Model Compound: Synthesis and Enantioselective Reduction of Benzoylformates to the Corresponding Mandelates. Molecules. 2007; 12(5):979-987. https://doi.org/10.3390/12050979

Chicago/Turabian Style

Zhao, Jia, Nai-Xing Wang, Wu-Wei Wang, Yan-Hong Liu, Li Li, Gui-Xia Wang, Jin-Lan Yu, and Xin-Liang Tang. 2007. "A New Type of NADH Model Compound: Synthesis and Enantioselective Reduction of Benzoylformates to the Corresponding Mandelates" Molecules 12, no. 5: 979-987. https://doi.org/10.3390/12050979

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