Next Article in Journal
Determination of the Three-dimensional Structure of Gynoside A in Solution using NMR and Molecular Modeling
Previous Article in Journal
Synthesis and Activity of a New Series of(Z)-3-Phenyl-2-benzoylpropenoic Acid Derivatives as Aldose Reductase Inhibitors
Article Menu

Export Article

Open AccessArticle
Molecules 2007, 12(4), 896-906; doi:10.3390/12040896

4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents

1
Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), Itajaí-SC, Brazil
2
Departamento de Química, Universidade Federal de Santa Catarina (UFSC), Florianópolis-SC, Brazil
*
Author to whom correspondence should be addressed.
Received: 22 March 2007 / Revised: 22 April 2007 / Accepted: 24 April 2007 / Published: 30 April 2007
View Full-Text   |   Download PDF [59 KB, uploaded 18 June 2014]   |  

Abstract

Nine acetamidochalcones were synthesized and evaluated as antinociceptive agents using the mice writhing test. Given intraperitoneally all the compounds were more effective than the two reference analgesic drugs (acetylsalicylic acid and acetaminophen) used for comparison. N-{4-[(2E)-3-(4-nitrophenyl)prop-2-enoyl]phenyl}acetamide (6) was the most effective compound and was therefore selected for more detailed studies. It caused dose-related inhibition in the writhing test, being about 32 to 34-fold more potent than the standard drugs. It was also effective in the second phase of the formalin test and the capsaicin test. These acetamidochalcones, especially compound 6, might be further used as models to obtain new and more potent analgesic drugs. View Full-Text
Keywords: Acetamidochalcones; antinociception; mice Acetamidochalcones; antinociception; mice
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

De Campos-Buzzi, F.; Padaratz, P.; Meira, A.V.; Corrêa, R.; Nunes, R.J.; Cechinel-Filho, V. 4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents. Molecules 2007, 12, 896-906.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top