Next Article in Journal
Previous Article in Journal
Molecules 2007, 12(4), 896-906; doi:10.3390/12040896
Article

4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents

1, 1, 1, 1, 2 and 1,*
Received: 22 March 2007; in revised form: 22 April 2007 / Accepted: 24 April 2007 / Published: 30 April 2007
Download PDF [59 KB, uploaded 18 June 2014]
Abstract: Nine acetamidochalcones were synthesized and evaluated as antinociceptive agents using the mice writhing test. Given intraperitoneally all the compounds were more effective than the two reference analgesic drugs (acetylsalicylic acid and acetaminophen) used for comparison. N-{4-[(2E)-3-(4-nitrophenyl)prop-2-enoyl]phenyl}acetamide (6) was the most effective compound and was therefore selected for more detailed studies. It caused dose-related inhibition in the writhing test, being about 32 to 34-fold more potent than the standard drugs. It was also effective in the second phase of the formalin test and the capsaicin test. These acetamidochalcones, especially compound 6, might be further used as models to obtain new and more potent analgesic drugs.
Keywords: Acetamidochalcones; antinociception; mice Acetamidochalcones; antinociception; mice
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

De Campos-Buzzi, F.; Padaratz, P.; Meira, A.V.; Corrêa, R.; Nunes, R.J.; Cechinel-Filho, V. 4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents. Molecules 2007, 12, 896-906.

AMA Style

De Campos-Buzzi F, Padaratz P, Meira AV, Corrêa R, Nunes RJ, Cechinel-Filho V. 4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents. Molecules. 2007; 12(4):896-906.

Chicago/Turabian Style

De Campos-Buzzi, Fátima; Padaratz, Pâmela; Meira, Aleandra V.; Corrêa, Rogério; Nunes, Ricardo J.; Cechinel-Filho, Valdir. 2007. "4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents." Molecules 12, no. 4: 896-906.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert