4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents

doi:10.3390/12040896

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Molecules 2007, 12(4), 896-906; doi:10.3390/12040896

Article

4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents

Fátima De Campos-Buzzi¹, Pâmela Padaratz¹, Aleandra Vergilina Meira¹, Rogério Corrêa¹, Ricardo José Nunes² and Valdir Cechinel-Filho^1,*

¹ Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), Itajaí-SC, Brazil ² Departamento de Química, Universidade Federal de Santa Catarina (UFSC), Florianópolis-SC, Brazil

* Author to whom correspondence should be addressed.

Received: 22 March 2007; in revised form: 22 April 2007 / Accepted: 24 April 2007 / Published: 30 April 2007

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Abstract: Nine acetamidochalcones were synthesized and evaluated as antinociceptive agents using the mice writhing test. Given intraperitoneally all the compounds were more effective than the two reference analgesic drugs (acetylsalicylic acid and acetaminophen) used for comparison. N-{4-[(2E)-3-(4-nitrophenyl)prop-2-enoyl]phenyl}acetamide (6) was the most effective compound and was therefore selected for more detailed studies. It caused dose-related inhibition in the writhing test, being about 32 to 34-fold more potent than the standard drugs. It was also effective in the second phase of the formalin test and the capsaicin test. These acetamidochalcones, especially compound 6, might be further used as models to obtain new and more potent analgesic drugs.

Keywords: Acetamidochalcones; antinociception; mice

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MDPI and ACS Style

De Campos-Buzzi, F.; Padaratz, P.; Meira, A.V.; Corrêa, R.; Nunes, R.J.; Cechinel-Filho, V. 4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents. Molecules 2007, 12, 896-906.

AMA Style

De Campos-Buzzi F, Padaratz P, Meira AV, Corrêa R, Nunes RJ, Cechinel-Filho V. 4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents. Molecules. 2007; 12(4):896-906.

Chicago/Turabian Style

De Campos-Buzzi, Fátima; Padaratz, Pâmela; Meira, Aleandra V.; Corrêa, Rogério; Nunes, Ricardo J.; Cechinel-Filho, Valdir. 2007. "4'-Acetamidochalcone Derivatives as Potential Antinociceptive Agents." Molecules 12, no. 4: 896-906.

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