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Retraction published on 10 September 2007, see Molecules 2007, 12(9), 2160.

Molecules 2007, 12(3), 673-678; doi:10.3390/12030673

Synthesis of Gefitinibfrom Methyl 3-Hydroxy-4-methoxy-benzoate

 and *
Institute of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Jiangsu Laboratory for Biomaterials and Devices, Southeast University, 210096 Nanjing, P. R. China
* Author to whom correspondence should be addressed.
Received: 9 March 2007 / Revised: 22 March 2007 / Accepted: 23 March 2007 / Published: 28 March 2007
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This paper reports a novel synthesis of gefitinib starting from methyl3-hydroxy-4-methoxybenzoate. The process starts with alkylation of the starting material, followed by nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates andtarget molecule were characterized by 1H-NMR, 13C-NMR, MSand the purities of all these compounds were determined by HPLC. This novelsynthetic route produced overall yields as high as 37.4%.
Keywords: Gefitinib; tyrosine kinase inhibitors; methyl 3-hydroxy-4-methoxybenzoate Gefitinib; tyrosine kinase inhibitors; methyl 3-hydroxy-4-methoxybenzoate
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Li, M.D.; Zheng, Y.G.; Ji, M. Synthesis of Gefitinibfrom Methyl 3-Hydroxy-4-methoxy-benzoate. Molecules 2007, 12, 673-678.

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