Synthesis of Gefitinibfrom Methyl 3-Hydroxy-4-methoxy-benzoate
AbstractThis paper reports a novel synthesis of gefitinib starting from methyl3-hydroxy-4-methoxybenzoate. The process starts with alkylation of the starting material, followed by nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates andtarget molecule were characterized by 1H-NMR, 13C-NMR, MSand the purities of all these compounds were determined by HPLC. This novelsynthetic route produced overall yields as high as 37.4%.
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Li, M.D.; Zheng, Y.G.; Ji, M. Synthesis of Gefitinibfrom Methyl 3-Hydroxy-4-methoxy-benzoate. Molecules 2007, 12, 673-678.
Li MD, Zheng YG, Ji M. Synthesis of Gefitinibfrom Methyl 3-Hydroxy-4-methoxy-benzoate. Molecules. 2007; 12(3):673-678.Chicago/Turabian Style
Li, Ming D.; Zheng, You G.; Ji, Min. 2007. "Synthesis of Gefitinibfrom Methyl 3-Hydroxy-4-methoxy-benzoate." Molecules 12, no. 3: 673-678.