This paper was retracted on 10 September 2007, see Molecules 2007, 12(9), 2160.

Molecules 2007, 12(3), 673-678; doi:10.3390/12030673

Synthesis of Gefitinibfrom Methyl 3-Hydroxy-4-methoxy-benzoate

email,  and * email
Received: 9 March 2007; in revised form: 22 March 2007 / Accepted: 23 March 2007 / Published: 28 March 2007
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This paper reports a novel synthesis of gefitinib starting from methyl3-hydroxy-4-methoxybenzoate. The process starts with alkylation of the starting material, followed by nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates andtarget molecule were characterized by 1H-NMR, 13C-NMR, MSand the purities of all these compounds were determined by HPLC. This novelsynthetic route produced overall yields as high as 37.4%.
Keywords: Gefitinib; tyrosine kinase inhibitors; methyl 3-hydroxy-4-methoxybenzoate
PDF Full-text Download PDF Full-Text [60 KB, uploaded 18 June 2014 19:27 CEST]

Export to BibTeX |

MDPI and ACS Style

Li, M.D.; Zheng, Y.G.; Ji, M. Synthesis of Gefitinibfrom Methyl 3-Hydroxy-4-methoxy-benzoate. Molecules 2007, 12, 673-678.

AMA Style

Li MD, Zheng YG, Ji M. Synthesis of Gefitinibfrom Methyl 3-Hydroxy-4-methoxy-benzoate. Molecules. 2007; 12(3):673-678.

Chicago/Turabian Style

Li, Ming D.; Zheng, You G.; Ji, Min. 2007. "Synthesis of Gefitinibfrom Methyl 3-Hydroxy-4-methoxy-benzoate." Molecules 12, no. 3: 673-678.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert