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Molecules 2007, 12(3), 415-422; doi:10.3390/12030415
Article

N-Methyl-(R)-3-(tert-Butyl)-Sulfinyl-1,4-Dihydropyridine: A Novel NADH Model Compound

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Received: 25 February 2007; in revised form: 7 March 2007 / Accepted: 7 March 2007 / Published: 12 March 2007
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Abstract: We have synthesized a novel chiral NADH model compound, N-methyl-(R)-3-(tert-butyl)-sulphinyl-1,4-dihydropyridine with high enantioselectivity and used it in the reduction of methyl benzoylformate, producing (S)-methyl mandelate in 95% ee. The absolute structure of its precursor, 3-(tert-butyl)sulfinyl pyridine, was determined by X-ray analysis.
Keywords: NADH model compound; chiral; sulfoxide; dihydropyridine; synthesis NADH model compound; chiral; sulfoxide; dihydropyridine; synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Xie, K.; Liu, Y.-C.; Cui, Y.; Wang, J.-G.; Fu, Y.; Mak, T.C. N-Methyl-(R)-3-(tert-Butyl)-Sulfinyl-1,4-Dihydropyridine: A Novel NADH Model Compound. Molecules 2007, 12, 415-422.

AMA Style

Xie K, Liu Y-C, Cui Y, Wang J-G, Fu Y, Mak TC. N-Methyl-(R)-3-(tert-Butyl)-Sulfinyl-1,4-Dihydropyridine: A Novel NADH Model Compound. Molecules. 2007; 12(3):415-422.

Chicago/Turabian Style

Xie, Kun; Liu, You-Cheng; Cui, Yi; Wang, Jian-Ge; Fu, Yao; Mak, Thomas C. 2007. "N-Methyl-(R)-3-(tert-Butyl)-Sulfinyl-1,4-Dihydropyridine: A Novel NADH Model Compound." Molecules 12, no. 3: 415-422.


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