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Molecules 2007, 12(3), 328-344; doi:10.3390/12030328
Article

Acylated Flavone Glycosides from the Roots of Saussurea lappa and Their Antifungal Activity

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Received: 14 November 2006 / Revised: 20 February 2007 / Accepted: 21 February 2007 / Published: 7 March 2007
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Abstract

The isolation of four novel acylated flavonoid glycosides from the roots of Saussurea lappa and their identification using a combination of 1D and 2D NMR and mass spectrometry is described. The in vitro antifungal and antibacterial activities of the isolated compounds and their mixture were tested on nine fungal and four bacterial strains, using the microdilution method. The compounds and mixture showed moderate to high antifungal activity against most of the fungi tested, compared to a miconazole standard, while only one compound and the mixture showed antibacterial activity against all strains tested.
Keywords: Saussurea lappa; acylated flavone glycosides; scutellarein; kaempferol; antifungal acitivity Saussurea lappa; acylated flavone glycosides; scutellarein; kaempferol; antifungal acitivity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rao, K.S.; Babu, G.V.; Ramnareddy, Y.V. Acylated Flavone Glycosides from the Roots of Saussurea lappa and Their Antifungal Activity. Molecules 2007, 12, 328-344.

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