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Acylated Flavone Glycosides from the Roots of Saussurea lappa and Their Antifungal Activity
School of Studies in Chemistry, Vikram University, Ujjain 456010, M.P. India
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Received: 14 November 2006; in revised form: 20 February 2007 / Accepted: 21 February 2007 / Published: 7 March 2007
Abstract: The isolation of four novel acylated flavonoid glycosides from the roots of Saussurea lappa and their identification using a combination of 1D and 2D NMR and mass spectrometry is described. The in vitro antifungal and antibacterial activities of the isolated compounds and their mixture were tested on nine fungal and four bacterial strains, using the microdilution method. The compounds and mixture showed moderate to high antifungal activity against most of the fungi tested, compared to a miconazole standard, while only one compound and the mixture showed antibacterial activity against all strains tested.
Keywords: Saussurea lappa; acylated flavone glycosides; scutellarein; kaempferol; antifungal acitivity
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Rao, K.S.; Babu, G.V.; Ramnareddy, Y.V. Acylated Flavone Glycosides from the Roots of Saussurea lappa and Their Antifungal Activity. Molecules 2007, 12, 328-344.
Rao KS, Babu GV, Ramnareddy YV. Acylated Flavone Glycosides from the Roots of Saussurea lappa and Their Antifungal Activity. Molecules. 2007; 12(3):328-344.
Rao, Kolisetty S.; Babu, Goriparthi V.; Ramnareddy, Yemireddy V. 2007. "Acylated Flavone Glycosides from the Roots of Saussurea lappa and Their Antifungal Activity." Molecules 12, no. 3: 328-344.