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Molecules 2007, 12(2), 139-148; doi:10.3390/12020139

Antibacterial Activity of Long-Chain Fatty Alcohols against Staphylococcus aureus

1, 1, 1, 2, 2, 3 and 1,*
Received: 13 January 2007 / Revised: 31 January 2007 / Accepted: 2 February 2007 / Published: 5 February 2007
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The antibacterial activity against Staphylococcus aureus of long-chain fatty alcohols was investigated, with a focus on normal alcohols. The antibacterial activity varied with the length of the aliphatic carbon chain and not with the water/octanol partition coefficient. 1-Nonanol, 1-decanol and 1-undecanol had bactericidal activity and membrane-damaging activity. 1-Dodecanol and 1-tridecanol had the highest antibacterial activity among the long-chain fatty alcohols tested, but had no membrane-damaging activity. Consequently, it appears that not only the antibacterial activity but also the mode of action of long-chain fatty alcohols might be determined by the length of the aliphatic carbon chain.
Keywords: Staphylococcus aureus;fatty alcohols;antibacterial activity;length of carbon chain;K+ ion leakage. Staphylococcus aureus; fatty alcohols; antibacterial activity; length of carbon chain; K+ ion leakage.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Togashi, N.; Shiraishi, A.; Nishizaka, M.; Matsuoka, K.; Endo, K.; Hamashima, H.; Inoue, Y. Antibacterial Activity of Long-Chain Fatty Alcohols against Staphylococcus aureus. Molecules 2007, 12, 139-148.

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