Abstract: The antibacterial activity against Staphylococcus aureus of long-chain fatty alcohols was investigated, with a focus on normal alcohols. The antibacterial activity varied with the length of the aliphatic carbon chain and not with the water/octanol partition coefficient. 1-Nonanol, 1-decanol and 1-undecanol had bactericidal activity and membrane-damaging activity. 1-Dodecanol and 1-tridecanol had the highest antibacterial activity among the long-chain fatty alcohols tested, but had no membrane-damaging activity. Consequently, it appears that not only the antibacterial activity but also the mode of action of long-chain fatty alcohols might be determined by the length of the aliphatic carbon chain.
Keywords: Staphylococcus aureus;fatty alcohols;antibacterial activity;length of carbon chain;K+ ion leakage.
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Togashi, N.; Shiraishi, A.; Nishizaka, M.; Matsuoka, K.; Endo, K.; Hamashima, H.; Inoue, Y. Antibacterial Activity of Long-Chain Fatty Alcohols against Staphylococcus aureus. Molecules 2007, 12, 139-148.
Togashi N, Shiraishi A, Nishizaka M, Matsuoka K, Endo K, Hamashima H, Inoue Y. Antibacterial Activity of Long-Chain Fatty Alcohols against Staphylococcus aureus. Molecules. 2007; 12(2):139-148.
Togashi, Naoko; Shiraishi, Akiko; Nishizaka, Miki; Matsuoka, Keisuke; Endo, Kazutoyo; Hamashima, Hajime; Inoue, Yoshihiro. 2007. "Antibacterial Activity of Long-Chain Fatty Alcohols against Staphylococcus aureus." Molecules 12, no. 2: 139-148.