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Molecules 2007, 12(11), 2533-2545; doi:10.3390/12112533

Synthesis of New L-Ascorbic Ferulic Acid Hybrids

, ,  and *
Université de Caen Basse-Normandie, U.F.R. des Sciences Pharmaceutiques, Centre d’Etudes et de Recherche sur le Médicament de Normandie, UPRES EA-3915, 5, rue Vaubénard, 14032 CAEN Cedex, France
* Author to whom correspondence should be addressed.
Received: 30 October 2007 / Revised: 15 November 2007 / Accepted: 15 November 2007 / Published: 17 November 2007
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A feasibility and chemical study of the coupling conditions of L-ascorbic acidwith ferulic acid derivatives are described on the basis of the known synergistic effects ofmixtures of various antioxidants. Novel L-ascorbic ferulic hybrids linked at the C-3hydroxyl group were prepared with the aim to protect the alcohol function and the enediolsystem.
Keywords: Ascorbic acid; ferulic acid; hybridization; antioxidant; oxidative stress. Ascorbic acid; ferulic acid; hybridization; antioxidant; oxidative stress.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Voisin-Chiret, A.S.; Bazin, M.-A.; Lancelot, J.-C.; Rault, S. Synthesis of New L-Ascorbic Ferulic Acid Hybrids. Molecules 2007, 12, 2533-2545.

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