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Molecules 2006, 11(9), 693-699; doi:10.3390/11090693
Communication

Cytotoxicity of Two Triterpenoids from Nigella glandulifera

1,* , 1, 1, 1, 1, 3 and 2,*
Received: 25 July 2006 / Revised: 28 August 2006 / Accepted: 30 August 2006 / Published: 13 September 2006
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Abstract

During an investigation of antitumor substances from Nigella glandulifera Freyn et Sint. (Ranunculaceae) the cytotoxicity of two oleanane triterpene saponins isolated from the seeds of this species, kalopanaxsaponins A and I, was evaluated against HepG2, drug resistant HepG2 (R-HepG2) (two hepatocyte cell lines) and primary cultured normal mouse hepatocytes. Evident cytotoxic activities were observed. Morphological observations and cell cycle analysis suggest that these compounds inhibit the proliferation of hepatoma by inducing apoptosis and consequently kalopanaxsaponins A and I may be potential therapeutic agents for the treatment of parental and drug resistant hepatoma.
Keywords: Nigella glandulifera; oleanane type saponins; cytotoxicity; HepG2; apoptosis Nigella glandulifera; oleanane type saponins; cytotoxicity; HepG2; apoptosis
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Tian, Z.; Liu, Y.-M.; Chen, S.-B.; Yang, J.-S.; Xiao, P.-G.; Wang, L.; Wu, E. Cytotoxicity of Two Triterpenoids from Nigella glandulifera. Molecules 2006, 11, 693-699.

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