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Molecules 2006, 11(9), 693-699; doi:10.3390/11090693

Cytotoxicity of Two Triterpenoids from Nigella glandulifera

1,* , 1, 1, 1, 1, 3 and 2,*
1 Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100094, P.R. China 2 Children’s Hospital Informatics Program at Harvard–MIT Division of Health Sciences and Technology, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, U.S.A. 3 College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, P.R. China
* Authors to whom correspondence should be addressed.
Received: 25 July 2006 / Revised: 28 August 2006 / Accepted: 30 August 2006 / Published: 13 September 2006
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During an investigation of antitumor substances from Nigella glandulifera Freyn et Sint. (Ranunculaceae) the cytotoxicity of two oleanane triterpene saponins isolated from the seeds of this species, kalopanaxsaponins A and I, was evaluated against HepG2, drug resistant HepG2 (R-HepG2) (two hepatocyte cell lines) and primary cultured normal mouse hepatocytes. Evident cytotoxic activities were observed. Morphological observations and cell cycle analysis suggest that these compounds inhibit the proliferation of hepatoma by inducing apoptosis and consequently kalopanaxsaponins A and I may be potential therapeutic agents for the treatment of parental and drug resistant hepatoma.
Keywords: Nigella glandulifera; oleanane type saponins; cytotoxicity; HepG2; apoptosis Nigella glandulifera; oleanane type saponins; cytotoxicity; HepG2; apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tian, Z.; Liu, Y.-M.; Chen, S.-B.; Yang, J.-S.; Xiao, P.-G.; Wang, L.; Wu, E. Cytotoxicity of Two Triterpenoids from Nigella glandulifera. Molecules 2006, 11, 693-699.

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