Next Article in Journal
An Efficient Synthesis of a Spirocyclic Oxindole Analogue
Previous Article in Journal
Synthesis and Characterisation of Eight Isomeric Bis(2-pyridyloxy)naphthalenes
Article Menu

Export Article

Open AccessCommunication
Molecules 2006, 11(9), 693-699; doi:10.3390/11090693

Cytotoxicity of Two Triterpenoids from Nigella glandulifera

1
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100094, P.R. China
2
Children’s Hospital Informatics Program at Harvard–MIT Division of Health Sciences and Technology, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, U.S.A.
3
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, P.R. China
*
Authors to whom correspondence should be addressed.
Received: 25 July 2006 / Revised: 28 August 2006 / Accepted: 30 August 2006 / Published: 13 September 2006
View Full-Text   |   Download PDF [174 KB, uploaded 18 June 2014]   |  

Abstract

During an investigation of antitumor substances from Nigella glandulifera Freyn et Sint. (Ranunculaceae) the cytotoxicity of two oleanane triterpene saponins isolated from the seeds of this species, kalopanaxsaponins A and I, was evaluated against HepG2, drug resistant HepG2 (R-HepG2) (two hepatocyte cell lines) and primary cultured normal mouse hepatocytes. Evident cytotoxic activities were observed. Morphological observations and cell cycle analysis suggest that these compounds inhibit the proliferation of hepatoma by inducing apoptosis and consequently kalopanaxsaponins A and I may be potential therapeutic agents for the treatment of parental and drug resistant hepatoma. View Full-Text
Keywords: Nigella glandulifera; oleanane type saponins; cytotoxicity; HepG2; apoptosis Nigella glandulifera; oleanane type saponins; cytotoxicity; HepG2; apoptosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Tian, Z.; Liu, Y.-M.; Chen, S.-B.; Yang, J.-S.; Xiao, P.-G.; Wang, L.; Wu, E. Cytotoxicity of Two Triterpenoids from Nigella glandulifera. Molecules 2006, 11, 693-699.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top