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Molecules 2006, 11(7), 523-527; doi:10.3390/11070523

[Hydroxy(tosyloxy)iodo]benzene Mediated α-Azidation of Ketones

* , ,  and
Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India
* Author to whom correspondence should be addressed.
Received: 20 August 2005 / Revised: 10 March 2006 / Accepted: 12 March 2006 / Published: 14 July 2006
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Reaction of various ketones with [hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment of the α-tosyloxy ketones thus generated in situ with NaN3 offers a one-pot procedure for the synthesis of α-azido ketones. The HTIB used in this conversion may also be generated in situ by using iodosobenzene in combination with p-toluene- sulphonic acid.
Keywords: Hypervalent iodine; α-azido ketones; [hydroxy(tosyloxy)iodo]benzene; iodosobenzene. Hypervalent iodine; α-azido ketones; [hydroxy(tosyloxy)iodo]benzene; iodosobenzene.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Prakash, O.; Pannu, K.; Prakash, R.; Batra, A. [Hydroxy(tosyloxy)iodo]benzene Mediated α-Azidation of Ketones. Molecules 2006, 11, 523-527.

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