Molecules 2006, 11(6), 383-392; doi:10.3390/11060383
Article

Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives

Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. China
* Author to whom correspondence should be addressed.
Received: 26 April 2006; Accepted: 12 June 2006 / Published: 12 June 2006
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Abstract: A simple, efficient, and general method has been developed for the synthesis ofvarious 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkylbromides under phase transfer catalysis condition. The structures of the compounds werecharacterized by elemental analysis, IR, 1H-NMR and 13C-NMR spectra. Title compound6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity.
Keywords: Quinazolinone; Phase Transfer Catalyst; synthesis; antifungal activity

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MDPI and ACS Style

Ouyang, G.; Zhang, P.; Xu, G.; Song, B.; Yang, S.; Jin, L.; Xue, W.; Hu, D.; Lu, P.; Chen, Z. Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives. Molecules 2006, 11, 383-392.

AMA Style

Ouyang G, Zhang P, Xu G, Song B, Yang S, Jin L, Xue W, Hu D, Lu P, Chen Z. Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives. Molecules. 2006; 11(6):383-392.

Chicago/Turabian Style

Ouyang, Guiping; Zhang, Peiquan; Xu, Gangfang; Song, Baoan; Yang, Song; Jin, Linhong; Xue, Wei; Hu, Deyu; Lu, Ping; Chen, Zhuo. 2006. "Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives." Molecules 11, no. 6: 383-392.

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