Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives

doi:10.3390/11060383

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Molecules 2006, 11(6), 383-392; doi:10.3390/11060383

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Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives

Guiping Ouyang, Peiquan Zhang, Gangfang Xu, Baoan Song* , Song Yang, Linhong Jin, Wei Xue, Deyu Hu, Ping Lu and Zhuo Chen

Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. China

* Author to whom correspondence should be addressed.

Received: 26 April 2006 / Accepted: 12 June 2006 / Published: 12 June 2006

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Abstract: A simple, efficient, and general method has been developed for the synthesis ofvarious 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkylbromides under phase transfer catalysis condition. The structures of the compounds werecharacterized by elemental analysis, IR, ¹H-NMR and ¹³C-NMR spectra. Title compound6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity.

Keywords: Quinazolinone; Phase Transfer Catalyst; synthesis; antifungal activity

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MDPI and ACS Style

Ouyang, G.; Zhang, P.; Xu, G.; Song, B.; Yang, S.; Jin, L.; Xue, W.; Hu, D.; Lu, P.; Chen, Z. Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives. Molecules 2006, 11, 383-392.

AMA Style

Ouyang G, Zhang P, Xu G, Song B, Yang S, Jin L, Xue W, Hu D, Lu P, Chen Z. Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives. Molecules. 2006; 11(6):383-392.

Chicago/Turabian Style

Ouyang, Guiping; Zhang, Peiquan; Xu, Gangfang; Song, Baoan; Yang, Song; Jin, Linhong; Xue, Wei; Hu, Deyu; Lu, Ping; Chen, Zhuo. 2006. "Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives." Molecules 11, no. 6: 383-392.

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