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Molecules 2006, 11(6), 383-392; doi:10.3390/11060383

Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives

Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. China
Author to whom correspondence should be addressed.
Received: 26 April 2006 / Accepted: 12 June 2006 / Published: 12 June 2006
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A simple, efficient, and general method has been developed for the synthesis ofvarious 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkylbromides under phase transfer catalysis condition. The structures of the compounds werecharacterized by elemental analysis, IR, 1H-NMR and 13C-NMR spectra. Title compound6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity. View Full-Text
Keywords: Quinazolinone; Phase Transfer Catalyst; synthesis; antifungal activity Quinazolinone; Phase Transfer Catalyst; synthesis; antifungal activity

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MDPI and ACS Style

Ouyang, G.; Zhang, P.; Xu, G.; Song, B.; Yang, S.; Jin, L.; Xue, W.; Hu, D.; Lu, P.; Chen, Z. Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives. Molecules 2006, 11, 383-392.

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