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Molecules 2006, 11(6), 383-392; doi:10.3390/11060383

Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives

Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. China
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Received: 26 April 2006 / Accepted: 12 June 2006 / Published: 12 June 2006
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Abstract

A simple, efficient, and general method has been developed for the synthesis ofvarious 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkylbromides under phase transfer catalysis condition. The structures of the compounds werecharacterized by elemental analysis, IR, 1H-NMR and 13C-NMR spectra. Title compound6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity. View Full-Text
Keywords: Quinazolinone; Phase Transfer Catalyst; synthesis; antifungal activity Quinazolinone; Phase Transfer Catalyst; synthesis; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ouyang, G.; Zhang, P.; Xu, G.; Song, B.; Yang, S.; Jin, L.; Xue, W.; Hu, D.; Lu, P.; Chen, Z. Synthesis and Antifungal Bioactivities of 3-Alkylquinazolin- 4-one Derivatives. Molecules 2006, 11, 383-392.

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