A Simple Synthetic Route to Methyl 3-Fluoropyridine-4-carboxylate by Nucleophilic Aromatic Substitution

doi:10.3390/11020130

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Molecules 2006, 11(2), 130-133; doi:10.3390/11020130

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A Simple Synthetic Route to Methyl 3-Fluoropyridine-4-carboxylate by Nucleophilic Aromatic Substitution

Freddy Tjosaas and Anne Fiksdahl *

Department of Chemistry, Norwegian University of Science and Technology, NTNU N-7491 Trondheim, Norway

* Author to whom correspondence should be addressed.

Received: 25 January 2006 / Accepted: 24 February 2006 / Published: 25 February 2006

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Abstract: The nitro group of methyl 3-nitropyridine-4-carboxylate (1) has successfully been replaced by fluoride anion via nucleophilic aromatic substitution to give the 3-fluoro- pyridine-4-carboxylate 2.

Keywords: Methyl 3-fluoropyridine-4-carboxylate; methyl 3-nitropyridine-4-carboxylate; fluoride anion; nucleophilic aromatic substitution.

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MDPI and ACS Style

Tjosaas, F.; Fiksdahl, A. A Simple Synthetic Route to Methyl 3-Fluoropyridine-4-carboxylate by Nucleophilic Aromatic Substitution. Molecules 2006, 11, 130-133.

AMA Style

Tjosaas F., Fiksdahl A. A Simple Synthetic Route to Methyl 3-Fluoropyridine-4-carboxylate by Nucleophilic Aromatic Substitution. Molecules. 2006; 11(2):130-133.

Chicago/Turabian Style

Tjosaas, Freddy; Fiksdahl, Anne. 2006. "A Simple Synthetic Route to Methyl 3-Fluoropyridine-4-carboxylate by Nucleophilic Aromatic Substitution." Molecules 11, no. 2: 130-133.

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