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Molecules 2006, 11(11), 890-903; doi:10.3390/11110890
Article

Facile Synthesis of 5, 6, 7, 8-Tetrahydropyrimido [4, 5-b]-quinoline Derivatives

*  and
Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt
* Author to whom correspondence should be addressed.
Received: 18 October 2006 / Revised: 7 November 2006 / Accepted: 7 November 2006 / Published: 17 November 2006
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Abstract

2–Amino–4-phenyl–5,6,7,8–tetrahydroquinoline–3–carbonitrile (3) was synthesized by treating cyclohexanone (1) with 2–benzylidenemalononitrile (2) in the presence of ammonium acetate. The reactivity of compound 3 towards dimethylformamide dimethyl acetal (DMF-DMA), carbon disulfide, urea, thiourea, formamide, formic acid, acetyl chloride and isothiocyanate were studied. In addition, the antimicrobial activity of some selected derivatives is reported.
Keywords: Tetrahydroquinoline; pyrimidine; thioureide; pyrimidoquinoline; X-ray crystal structure. Tetrahydroquinoline; pyrimidine; thioureide; pyrimidoquinoline; X-ray crystal structure.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Elkholy, Y.M.; Morsy, M.A. Facile Synthesis of 5, 6, 7, 8-Tetrahydropyrimido [4, 5-b]-quinoline Derivatives. Molecules 2006, 11, 890-903.

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