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Molecules 2006, 11(11), 890-903; doi:10.3390/11110890
Article

Facile Synthesis of 5, 6, 7, 8-Tetrahydropyrimido [4, 5-b]-quinoline Derivatives

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Received: 18 October 2006 / Revised: 7 November 2006 / Accepted: 7 November 2006 / Published: 17 November 2006
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Abstract

2–Amino–4-phenyl–5,6,7,8–tetrahydroquinoline–3–carbonitrile (3) was synthesized by treating cyclohexanone (1) with 2–benzylidenemalononitrile (2) in the presence of ammonium acetate. The reactivity of compound 3 towards dimethylformamide dimethyl acetal (DMF-DMA), carbon disulfide, urea, thiourea, formamide, formic acid, acetyl chloride and isothiocyanate were studied. In addition, the antimicrobial activity of some selected derivatives is reported.
Keywords: Tetrahydroquinoline; pyrimidine; thioureide; pyrimidoquinoline; X-ray crystal structure. Tetrahydroquinoline; pyrimidine; thioureide; pyrimidoquinoline; X-ray crystal structure.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Elkholy, Y.M.; Morsy, M.A. Facile Synthesis of 5, 6, 7, 8-Tetrahydropyrimido [4, 5-b]-quinoline Derivatives. Molecules 2006, 11, 890-903.

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