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Facile Synthesis of 5, 6, 7, 8-Tetrahydropyrimido [4, 5-b]-quinoline Derivatives
Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt
* Author to whom correspondence should be addressed.
Received: 18 October 2006; in revised form: 7 November 2006 / Accepted: 7 November 2006 / Published: 17 November 2006
Abstract: 2–Amino–4-phenyl–5,6,7,8–tetrahydroquinoline–3–carbonitrile (3) was synthesized by treating cyclohexanone (1) with 2–benzylidenemalononitrile (2) in the presence of ammonium acetate. The reactivity of compound 3 towards dimethylformamide dimethyl acetal (DMF-DMA), carbon disulfide, urea, thiourea, formamide, formic acid, acetyl chloride and isothiocyanate were studied. In addition, the antimicrobial activity of some selected derivatives is reported.
Keywords: Tetrahydroquinoline; pyrimidine; thioureide; pyrimidoquinoline; X-ray crystal structure.
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MDPI and ACS Style
Elkholy, Y.M.; Morsy, M.A. Facile Synthesis of 5, 6, 7, 8-Tetrahydropyrimido [4, 5-b]-quinoline Derivatives. Molecules 2006, 11, 890-903.
Elkholy YM, Morsy MA. Facile Synthesis of 5, 6, 7, 8-Tetrahydropyrimido [4, 5-b]-quinoline Derivatives. Molecules. 2006; 11(11):890-903.
Elkholy, Yehya M.; Morsy, Mohamed A. 2006. "Facile Synthesis of 5, 6, 7, 8-Tetrahydropyrimido [4, 5-b]-quinoline Derivatives." Molecules 11, no. 11: 890-903.