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Molecules 2006, 11(10), 758-767; doi:10.3390/11100758

Synthesis and Natural Distribution of Anti-inflammatory Alkamides from Echinacea

1,* , 1, 2 and 2
1 Iowa State University Department of Chemistry, Ames, IA 50011, USA 2 Iowa State University Department of Genetics, Development and Cell Biology, Ames, IA 50011, USA
* Author to whom correspondence should be addressed.
Received: 2 September 2006 / Revised: 10 October 2006 / Accepted: 16 October 2006 / Published: 18 October 2006
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The synthesis of the alkamides 2Z,4E-undeca-2,4-dien-8,10-diynoic acid isobutyl amide (1) and 2Z,4E-undeca-2,4-dien-8,10-diynoic acid isobutyl amide (5) was accomplished by organometallic coupling followed by introduction of the doubly unsaturated amide moiety. The distribution of these two amides in accessions of the nine species of Echinacea was determined.
Keywords: Echinacea; alkamides; synthesis. Echinacea; alkamides; synthesis.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kraus, G.A.; Bae, J.; Wu, L.; Wurtele, E. Synthesis and Natural Distribution of Anti-inflammatory Alkamides from Echinacea. Molecules 2006, 11, 758-767.

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