Molecules 2006, 11(1), 49-58; doi:10.3390/11010049
Article

Synthesis of Novel N-Sulfonyl Monocyclic β-Lactams as Potential Antibacterial Agents

* email and
Received: 9 March 2005; in revised form: 12 December 2005 / Accepted: 14 December 2005 / Published: 31 January 2006
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: New cis monocyclic β-lactams were synthesized by [2+2] Staudinger cycloaddition reactions of the imine (3,4-dimethoxybenzylidene)-(4-methoxyphenyl)- amine and ketenes derived from different acyl chlorides and Et3N. These monocyclic β-lactams were then cleaved by ceric ammonium nitrate (CAN) to give NH-monocyclic β-lactams, which in turn were converted to N-sulfonyl monocyclic β-lactams by treatment with four different sulfonyl chlorides in the presence of Et3N and 4,4-dimethyl- aminopyridine (DMAP).
Keywords: 2-Azetidinones; N-Sulfonyl β-lactams; Ketene; Imine; CAN; DMAP
PDF Full-text Download PDF Full-Text [225 KB, uploaded 18 June 2014 19:27 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Jarrahpour, A.; Zarei, M. Synthesis of Novel N-Sulfonyl Monocyclic β-Lactams as Potential Antibacterial Agents. Molecules 2006, 11, 49-58.

AMA Style

Jarrahpour A, Zarei M. Synthesis of Novel N-Sulfonyl Monocyclic β-Lactams as Potential Antibacterial Agents. Molecules. 2006; 11(1):49-58.

Chicago/Turabian Style

Jarrahpour, Aliasghar; Zarei, Maaroof. 2006. "Synthesis of Novel N-Sulfonyl Monocyclic β-Lactams as Potential Antibacterial Agents." Molecules 11, no. 1: 49-58.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert