Poly[3-(3,4-dihydroxyphenyl)glyceric Acid], A New Biologically Active Polymer from Symphytum Asperum Lepech. and S.Caucasicum Bieb. (Boraginaceae)

doi:10.3390/10091135

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Molecules 2005, 10(9), 1135-1144; doi:10.3390/10091135

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Poly[3-(3,4-dihydroxyphenyl)glyceric Acid], A New Biologically Active Polymer from Symphytum Asperum Lepech. and S.Caucasicum Bieb. (Boraginaceae)

V. Barbakadze ¹^,* , E. Kemertelidze ¹, I. Targamadze ¹, K. Mulkijanyan ¹, A. Shashkov ² and A. Usov ²

¹ Kutateladze Institute of Pharmacochemistry, Georgian Academy of Sciences, Georgia ² Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Russia

* Author to whom correspondence should be addressed.

Received: 23 April 2005 / Accepted: 30 September 2005 / Published: 30 September 2005

(This article belongs to the Special Issue Selected Papers from the “2nd International Conference on Natural Products and Physiologically Active Substances” (ICNPAS-2004) and the 3rd EuroAsian Heterocyclic Meeting “Heterocycles in Organic and Combinatorial Chemistry”)

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Abstract: Two high-molecular water-soluble preparations with high anticomplementary, antioxidant, antilipoperoxidant and antiinflammatory activities were isolated from the roots of Symphytum asperum and S. caucasicum. Their main chemical constituent was found to be poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene], according to IR and NMR spectroscopy. The Symphytum high-molecular preparations can modulate in vitro B- chronic lymphocytic leukaemia (B-CLL) cells apoptosis and cell cycle progression.

Keywords: Caffeic acid; 3-(3; 4-dihydroxyphenyl)glyceric acid; Symphytum asperum; Symphytum asperum caucasicum; poly[oxy-1-carboxy-2-(3; 4-dihydroxyphenyl)ethylene].

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MDPI and ACS Style

Barbakadze, V.; Kemertelidze, E.; Targamadze, I.; Mulkijanyan, K.; Shashkov, A.; Usov, A. Poly[3-(3,4-dihydroxyphenyl)glyceric Acid], A New Biologically Active Polymer from Symphytum Asperum Lepech. and S.Caucasicum Bieb. (Boraginaceae). Molecules 2005, 10, 1135-1144.

AMA Style

Barbakadze V., Kemertelidze E., Targamadze I., Mulkijanyan K., Shashkov A., Usov A. Poly[3-(3,4-dihydroxyphenyl)glyceric Acid], A New Biologically Active Polymer from Symphytum Asperum Lepech. and S.Caucasicum Bieb. (Boraginaceae). Molecules. 2005; 10(9):1135-1144.

Chicago/Turabian Style

Barbakadze, V.; Kemertelidze, E.; Targamadze, I.; Mulkijanyan, K.; Shashkov, A.; Usov, A. 2005. "Poly[3-(3,4-dihydroxyphenyl)glyceric Acid], A New Biologically Active Polymer from Symphytum Asperum Lepech. and S.Caucasicum Bieb. (Boraginaceae)." Molecules 10, no. 9: 1135-1144.

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