A Facile Synthesis of Novel Herbicidal 1-Phenyl-piperazine-2,6-diones

doi:10.3390/10091119

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Molecules 2005, 10(9), 1119-1125; doi:10.3390/10091119

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A Facile Synthesis of Novel Herbicidal 1-Phenyl-piperazine-2,6-diones

B. Li ¹, D. Xiang ², C. Hsu ³, Z. Liu ², C. Wu ¹ and H. Yang ¹^,*

¹ State Key Laboratory of Elemento-Organic Chemistry, Nankai University, China ² Agrochemicals Division, Shenyang Research Institute of Chemical Industry, China ³ Applied Chemistry Department, Chaoyang University of Technology, Taiwan, China

* Author to whom correspondence should be addressed.

Received: 23 April 2005 / Accepted: 30 September 2005 / Published: 30 September 2005

(This article belongs to the Special Issue Selected Papers from the “2nd International Conference on Natural Products and Physiologically Active Substances” (ICNPAS-2004) and the 3rd EuroAsian Heterocyclic Meeting “Heterocycles in Organic and Combinatorial Chemistry”)

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Abstract: Novel 1-phenyl-piperazine-2,6-diones were prepared by a new facile synthetic routeusing methyl N-substituted iminomonoacetate as starting material. The structures of thesecompounds were established by ¹H-NMR, ¹³C-NMR and GC/MS. 2-(4-Chloro-5-cyclo-pentyl-oxy-2-fluorophenyl)-tetrahydro-2H-pyrido-[1,2-a]-pyrazine-1,3-(4H,6H)-dione displayed thegreatest herbicidal activity.

Keywords: 1-Phenyl-piperazine-2; 6-dione; 2-phenyl-tetrahydro-2H-pyrido-[1; 2-a]-pyrazine- 1; 3-(4H; 6H)-dione; 2-phenyl-tetrahydropyrrolo[1; 2-a]pyrazine-1; 3(2H; 4H)- dione; herbicide; synthesis.

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MDPI and ACS Style

Li, B.; Xiang, D.; Hsu, C.; Liu, Z.; Wu, C.; Yang, H. A Facile Synthesis of Novel Herbicidal 1-Phenyl-piperazine-2,6-diones. Molecules 2005, 10, 1119-1125.

AMA Style

Li B., Xiang D., Hsu C., Liu Z., Wu C., Yang H. A Facile Synthesis of Novel Herbicidal 1-Phenyl-piperazine-2,6-diones. Molecules. 2005; 10(9):1119-1125.

Chicago/Turabian Style

Li, B.; Xiang, D.; Hsu, C.; Liu, Z.; Wu, C.; Yang, H. 2005. "A Facile Synthesis of Novel Herbicidal 1-Phenyl-piperazine-2,6-diones." Molecules 10, no. 9: 1119-1125.

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