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Molecules 2005, 10(8), 937-960; doi:10.3390/10080937

Reactions of 3-Formylchromone with Active Methylene and Methyl Compounds and Some Subsequent Reactions of the Resulting Condensation Products

1
Department of Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius, Slovak Republic
2
Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Slovak Republic
*
Author to whom correspondence should be addressed.
Received: 12 March 2004 / Revised: 8 February 2005 / Accepted: 10 March 2005 / Published: 31 August 2005

Abstract

This review presents a survey of the condensations of 3-formylchromone with various active methylene and methyl compounds, e.g. malonic or barbituric acid derivatives, five-membered heterocycles, etc. The utilisation of the condensation products for the synthesis of different heterocyclic systems, which is based on the ability of the γ-pyrone ring to be opened by the nucleophilic attack is also reviewed. Finally, the applications of microwave irradiation as an unconventional method of reaction activation in the synthesis of condensation products is described and the biological activity of some chromone derivatives is noted.
Keywords: 3-Formylchromone; Knoevenagel condensation; active methylene compound; active methyl compound; microwave irradiation; biological activity. 3-Formylchromone; Knoevenagel condensation; active methylene compound; active methyl compound; microwave irradiation; biological activity.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Gasparová, R.; Lácova, M. Reactions of 3-Formylchromone with Active Methylene and Methyl Compounds and Some Subsequent Reactions of the Resulting Condensation Products. Molecules 2005, 10, 937-960.

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