Next Article in Journal / Special Issue
Photooxidation of Some Metallocenes in a Polymer Matrix
Previous Article in Journal / Special Issue
Immobilization of Chiral Ferrocenyl Ligands on Silica Gel and their Testing in Pd-catalyzed Allylic Substitution and Rh-catalyzed Hydrogenation
Molecules 2005, 10(6), 693-707; doi:10.3390/10060693
Article

Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection

, ,  and *
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan
* Author to whom correspondence should be addressed.
Received: 16 November 2004 / Accepted: 29 December 2004 / Published: 14 July 2005
(This article belongs to the Special Issue Synthesis and Chemistry of Chiral Metallocenes)
View Full-Text   |   Download PDF [358 KB, uploaded 18 June 2014]   |  

Abstract

Ferrocenylnaphthalene diimide 1 can bind to double stranded DNA (dsDNA) by the threading intercalation mode and the resulting complex was stabilized further by β- cyclodextrin (CD) by forming a supramolecular complex. These complex formation processes were studied by spectroscopic, viscometric, and electrochemical means in the absence or presence of β-CD. Quantitative analysis by quartz crystal microbalance (QCM) and electrochemical experiments strongly suggested a 2:1 binding stoichiometry for β-CD to 1 threading-intercalated to the dsDNA-immobilized electrode. Owing to this supramolecular complex formation, electrochemical DNA detection based on 1 was improved considerably.
Keywords: Ferrocenylnaphthalene diimide; β-cyclodextrin (CD); DNA; electrochemical detection; supramolecular complex Ferrocenylnaphthalene diimide; β-cyclodextrin (CD); DNA; electrochemical detection; supramolecular complex
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Sato, S.; Nojima, T.; Waki, M.; Takenaka, S. Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection. Molecules 2005, 10, 693-707.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert