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Molecules 2005, 10(6), 693-707; doi:10.3390/10060693
Article

Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection

, ,  and *
Received: 16 November 2004; Accepted: 29 December 2004 / Published: 14 July 2005
(This article belongs to the Special Issue Synthesis and Chemistry of Chiral Metallocenes)
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Abstract: Ferrocenylnaphthalene diimide 1 can bind to double stranded DNA (dsDNA) by the threading intercalation mode and the resulting complex was stabilized further by β- cyclodextrin (CD) by forming a supramolecular complex. These complex formation processes were studied by spectroscopic, viscometric, and electrochemical means in the absence or presence of β-CD. Quantitative analysis by quartz crystal microbalance (QCM) and electrochemical experiments strongly suggested a 2:1 binding stoichiometry for β-CD to 1 threading-intercalated to the dsDNA-immobilized electrode. Owing to this supramolecular complex formation, electrochemical DNA detection based on 1 was improved considerably.
Keywords: Ferrocenylnaphthalene diimide; β-cyclodextrin (CD); DNA; electrochemical detection; supramolecular complex Ferrocenylnaphthalene diimide; β-cyclodextrin (CD); DNA; electrochemical detection; supramolecular complex
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sato, S.; Nojima, T.; Waki, M.; Takenaka, S. Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection. Molecules 2005, 10, 693-707.

AMA Style

Sato S, Nojima T, Waki M, Takenaka S. Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection. Molecules. 2005; 10(6):693-707.

Chicago/Turabian Style

Sato, Shinobu; Nojima, Takahiko; Waki, Michinori; Takenaka, Shigeori. 2005. "Supramolecular Complex Formation by β-Cyclodextrin and Ferrocenylnaphthalene Diimide-intercalated Double Stranded DNA and Improved Electrochemical Gene Detection." Molecules 10, no. 6: 693-707.



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