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Molecules 2005, 10(3), 534-544; doi:10.3390/10030534
Article

Thermal Behaviour, Biological Activity and Conformational Study of a [Methoprene/β-Cyclodextrin] Complex in a Smoke Generating Formulation

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Received: 21 September 2004 / Revised: 20 January 2005 / Accepted: 21 January 2005 / Published: 13 May 2005
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Abstract

Methoprene, an insect growth regulator, was complexed with β-cyclodextrin, yielding a stable inclusion complex. TGA, X-ray powder diffraction and conformational analysis have been used to confirm the nature of this inclusion complex. The interaction between methoprene and β-cyclodextrin was investigated by means of Molecular Mechanics. The results account for the formation of a 1:1 inclusion complex stabilised by Van der Waals forces and hydrogen bonds. The [methoprene–β-cyclodextrin] complex included in smoke generating formulations and protected from thermal decomposition by the foaming agent azodicarbonamide was shown to be stable enough to release methoprene in fumes with good yields. The improved stabilty of the methoprene complex showed a correlation with increased biological activity against Musca domestica.
Keywords: Methoprene; β-cyclodextrin; molecular modelling; smoke generating formulation; thermal stability. Methoprene; β-cyclodextrin; molecular modelling; smoke generating formulation; thermal stability.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Audino, P.G.; Masuh, H.; Zerba, E. Thermal Behaviour, Biological Activity and Conformational Study of a [Methoprene/β-Cyclodextrin] Complex in a Smoke Generating Formulation. Molecules 2005, 10, 534-544.

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