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Molecules 2005, 10(2), 481-487; doi:10.3390/10020481
Article

A Novel Approach in Cinnamic Acid Synthesis: Direct Synthesis of Cinnamic Acids from Aromatic Aldehydes and Aliphatic Carboxylic Acids in the Presence of Boron Tribromide

* ,  and
Institute of Macromolecular Chemistry “Petru Poni”, Romania
* Author to whom correspondence should be addressed.
Received: 2 July 2004 / Revised: 2 February 2005 / Accepted: 3 February 2005 / Published: 28 February 2005
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Abstract

Cinnamic acids have been prepared in moderate to high yields by a new direct synthesis using aromatic aldehydes and aliphatic carboxylic acids, in the presence of boron tribromide as reagent, 4-dimethylaminopyridine (4-DMAP) and pyridine (Py) as bases and N-methyl-2-pyrolidinone (NMP) as solvent, at reflux (180-190°C) for 8-12 hours.
Keywords: Cinnamic acids; direct synthesis; boron tribromide/4-DMAP; activating agent. Cinnamic acids; direct synthesis; boron tribromide/4-DMAP; activating agent.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chiriac, C.; Tanasa, F.; Onciu, M. A Novel Approach in Cinnamic Acid Synthesis: Direct Synthesis of Cinnamic Acids from Aromatic Aldehydes and Aliphatic Carboxylic Acids in the Presence of Boron Tribromide. Molecules 2005, 10, 481-487.

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