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Molecules 2005, 10(2), 481-487; doi:10.3390/10020481
Article

A Novel Approach in Cinnamic Acid Synthesis: Direct Synthesis of Cinnamic Acids from Aromatic Aldehydes and Aliphatic Carboxylic Acids in the Presence of Boron Tribromide

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Received: 2 July 2004 / Revised: 2 February 2005 / Accepted: 3 February 2005 / Published: 28 February 2005
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Abstract

Cinnamic acids have been prepared in moderate to high yields by a new direct synthesis using aromatic aldehydes and aliphatic carboxylic acids, in the presence of boron tribromide as reagent, 4-dimethylaminopyridine (4-DMAP) and pyridine (Py) as bases and N-methyl-2-pyrolidinone (NMP) as solvent, at reflux (180-190°C) for 8-12 hours.
Keywords: Cinnamic acids; direct synthesis; boron tribromide/4-DMAP; activating agent. Cinnamic acids; direct synthesis; boron tribromide/4-DMAP; activating agent.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chiriac, C.; Tanasa, F.; Onciu, M. A Novel Approach in Cinnamic Acid Synthesis: Direct Synthesis of Cinnamic Acids from Aromatic Aldehydes and Aliphatic Carboxylic Acids in the Presence of Boron Tribromide. Molecules 2005, 10, 481-487.

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