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Molecules 2005, 10(2), 376-382; doi:10.3390/10020376
Article

Synthesis of 4-Amino-4,5-dihydro-1H-1,2,4-triazole-5-ones and their Isatin-3-imine Derivatives

Received: 12 July 2004 / Accepted: 1 September 2004 / Published: 28 February 2005
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Abstract

Iminoester hydrochlorides 1 have been synthesized. These compounds werethen converted into ester ethoxycarbonyl hydrazones 2, from which in turn a new seriesof substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones, 3, was then prepared.Finally a set of isatin imine derivatives 4 was obtained from the reaction of compounds 3with isatin. The structures of all the new synthesized compounds were confirmed byelemental analyses, IR, 1H-NMR and 13C-NMR spectra.
Keywords: Iminoesters; ethoxycarbonyl hydrazones; 4-amino-1; 2; 4-triazole-5-ones; isatin Iminoesters; ethoxycarbonyl hydrazones; 4-amino-1; 2; 4-triazole-5-ones; isatin
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Kahveci, B. Synthesis of 4-Amino-4,5-dihydro-1H-1,2,4-triazole-5-ones and their Isatin-3-imine Derivatives. Molecules 2005, 10, 376-382.

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