N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation †

doi:10.3390/10111387

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Molecules 2005, 10(11), 1387-1398; doi:10.3390/10111387

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N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation †

A. Bendjeddou, R. Djeribi, Z. Regainia and N. Aouf*

Laboratoire de Chimie Organique Appliquée. Groupe de Chimie Bioorganique, Faculté des Sciences. Département de Chimie. Université d’Annaba. Algeria

* Author to whom correspondence should be addressed.

Received: 28 June 2005; in revised form: 5 September 2005 / Accepted: 10 September 2005 / Published: 30 November 2005

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Abstract: The sulfamide functional group is increasingly relevant in both medicinal and bioorganic chemistry. We report here practical access to a series of N2,N5-substituted five-membered cyclosulfamides. The five-membered heterocyclic motif was prepared starting from proteogenic amino acids and chlorosulfonyl isocyanate via the Mitsunobu reaction. Selected chemical and spectral proprieties and the antimicrobial evaluation of these compounds are detailed.

Keywords: Amino acids; cyclic sulfamides; cyclization; Mitsunobu reaction; propionylation; constrained peptides.

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MDPI and ACS Style

Bendjeddou, A.; Djeribi, R.; Regainia, Z.; Aouf, N. N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation †. Molecules 2005, 10, 1387-1398.

AMA Style

Bendjeddou A, Djeribi R, Regainia Z, Aouf N. N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation †. Molecules. 2005; 10(11):1387-1398.

Chicago/Turabian Style

Bendjeddou, A.; Djeribi, R.; Regainia, Z.; Aouf, N. 2005. "N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation †." Molecules 10, no. 11: 1387-1398.

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