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Molecules 2005, 10(11), 1387-1398; doi:10.3390/10111387
Article

N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation †

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Received: 28 June 2005 / Revised: 5 September 2005 / Accepted: 10 September 2005 / Published: 30 November 2005
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Abstract

The sulfamide functional group is increasingly relevant in both medicinal and bioorganic chemistry. We report here practical access to a series of N2,N5-substituted five-membered cyclosulfamides. The five-membered heterocyclic motif was prepared starting from proteogenic amino acids and chlorosulfonyl isocyanate via the Mitsunobu reaction. Selected chemical and spectral proprieties and the antimicrobial evaluation of these compounds are detailed.
Keywords: Amino acids; cyclic sulfamides; cyclization; Mitsunobu reaction; propionylation; constrained peptides. Amino acids; cyclic sulfamides; cyclization; Mitsunobu reaction; propionylation; constrained peptides.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Bendjeddou, A.; Djeribi, R.; Regainia, Z.; Aouf, N. N,N’-Substituted 1,2,5 Thiadiazolidine 1,1-Dioxides: Synthesis, Selected Chemical and Spectral Proprieties and Antimicrobial Evaluation †. Molecules 2005, 10, 1387-1398.

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