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Molecules 2005, 10(11), 1377-1386; doi:10.3390/10111377
Article

Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines

1,* , 1 and 2
Received: 7 June 2005 / Revised: 25 October 2005 / Accepted: 26 November 2005 / Published: 30 November 2005
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Abstract

A series of 22 novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5- carboxamidine derivatives were synthesized and evaluated for in vitro antibacterial activity against S. aureus and methicillin resistant S. aureus (MRSA), E. coli, E. faecalis and for antifungal activity against C. albicans. Compound 59 [1-(2,4-dichlorobenzyl)-N- (2-diethylaminoethyl)-1H-benzimidazole-5-carboxamidine], with a 3,4-dichlorophenyl group at the C-2 position, displayed the greatest activity (MIC = 3.12 μg/mL against both some bacteria and the fungus C. albicans).
Keywords: 1H-Benzimidazole carboxamidines; methicillin-resistant S. aureus (MRSA); antibacterial activity and antifungal activity. 1H-Benzimidazole carboxamidines; methicillin-resistant S. aureus (MRSA); antibacterial activity and antifungal activity.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Göker, H.; Alp, M.; Yıldız, S. Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines. Molecules 2005, 10, 1377-1386.

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