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Molecules 2005, 10(11), 1377-1386; doi:10.3390/10111377

Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines

1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara-Turkey
2
Department of Microbiology, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey
*
Author to whom correspondence should be addressed.
Received: 7 June 2005 / Revised: 25 October 2005 / Accepted: 26 November 2005 / Published: 30 November 2005
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Abstract

A series of 22 novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5- carboxamidine derivatives were synthesized and evaluated for in vitro antibacterial activity against S. aureus and methicillin resistant S. aureus (MRSA), E. coli, E. faecalis and for antifungal activity against C. albicans. Compound 59 [1-(2,4-dichlorobenzyl)-N- (2-diethylaminoethyl)-1H-benzimidazole-5-carboxamidine], with a 3,4-dichlorophenyl group at the C-2 position, displayed the greatest activity (MIC = 3.12 μg/mL against both some bacteria and the fungus C. albicans).
Keywords: 1H-Benzimidazole carboxamidines; methicillin-resistant S. aureus (MRSA); antibacterial activity and antifungal activity. 1H-Benzimidazole carboxamidines; methicillin-resistant S. aureus (MRSA); antibacterial activity and antifungal activity.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Göker, H.; Alp, M.; Yıldız, S. Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines. Molecules 2005, 10, 1377-1386.

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