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Molecules 2005, 10(1), 295-301; doi:10.3390/10010295

Synthesis of Analogs of Amathamide A and Their Preliminary Antimicrobial Activity

Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, México
Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México
Instituto de Ciencia de Materiales de Barcelona (CSIC), Spain
Author to whom correspondence should be addressed.
Received: 20 August 2004 / Revised: 6 January 2005 / Accepted: 7 January 2005 / Published: 31 January 2005
(This article belongs to the Special Issue Hypervalent Iodine)
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Syntheses of three non-brominated analogs of amathamide A (1), a natural alkaloid isolated from the Tasmanian marine bryozoan Amathia wilsoni, are described. Antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomona aeruginosa, and Candida albicans was tested. Test results for amathamide A (1) showed a weak activity against C. albicans and E. coli. The three non-natural analogs 2-4 proved to be inactive compounds. View Full-Text
Keywords: Organic synthesis; Amathamide A; Antimicrobial activity. Organic synthesis; Amathamide A; Antimicrobial activity.

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MDPI and ACS Style

Ramírez-Osuna, M.; Chávez, D.; Hernández, L.; Molins, E.; Somanathan, R.; Aguirre, G. Synthesis of Analogs of Amathamide A and Their Preliminary Antimicrobial Activity. Molecules 2005, 10, 295-301.

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