Molecules 2005, 10(1), 295-301; doi:10.3390/10010295
Article

Synthesis of Analogs of Amathamide A and Their Preliminary Antimicrobial Activity

1 Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, México 2 Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México 3 Instituto de Ciencia de Materiales de Barcelona (CSIC), Spain
* Author to whom correspondence should be addressed.
Received: 20 August 2004; in revised form: 6 January 2005 / Accepted: 7 January 2005 / Published: 31 January 2005
(This article belongs to the Special Issue Hypervalent Iodine)
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Abstract: Syntheses of three non-brominated analogs of amathamide A (1), a natural alkaloid isolated from the Tasmanian marine bryozoan Amathia wilsoni, are described. Antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomona aeruginosa, and Candida albicans was tested. Test results for amathamide A (1) showed a weak activity against C. albicans and E. coli. The three non-natural analogs 2-4 proved to be inactive compounds.
Keywords: Organic synthesis; Amathamide A; Antimicrobial activity.

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MDPI and ACS Style

Ramírez-Osuna, M.; Chávez, D.; Hernández, L.; Molins, E.; Somanathan, R.; Aguirre, G. Synthesis of Analogs of Amathamide A and Their Preliminary Antimicrobial Activity. Molecules 2005, 10, 295-301.

AMA Style

Ramírez-Osuna M, Chávez D, Hernández L, Molins E, Somanathan R, Aguirre G. Synthesis of Analogs of Amathamide A and Their Preliminary Antimicrobial Activity. Molecules. 2005; 10(1):295-301.

Chicago/Turabian Style

Ramírez-Osuna, M.; Chávez, D.; Hernández, L.; Molins, E.; Somanathan, R.; Aguirre, G. 2005. "Synthesis of Analogs of Amathamide A and Their Preliminary Antimicrobial Activity." Molecules 10, no. 1: 295-301.

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