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Molecules 2005, 10(1), 279-288; doi:10.3390/10010279

Chemical and Photochemical Synthesis of Substituted Dihydro-thieno[2',3':4,5]thieno[2,3-c]quinolin-6-ones and Tetrahydro-dithieno[2,3-b:2',3'-d]thieno[2'',3''c:2'',3''c’]diquinolin-6,14-dione

Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, 10000 Zagreb, Croatia
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Received: 28 September 2004 / Revised: 2 November 2004 / Accepted: 30 December 2004 / Published: 31 January 2005
(This article belongs to the Special Issue Hypervalent Iodine)
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Abstract

Some new substituted dihydrothieno[2',3':4,5]thieno[2,3-c]quinolin-6-ones 9- 12 and tetrahydrodithieno[2,3-b: 2',3'-d]thieno[2'',3''-c:2'',3''-c’]diquinolin-6,14-dione (17) were prepared from the corresponding new anilides 5-8 and from the corresponding dianilide 15, respectively, by a multistep combination of chemical and photochemical reactions. All the prepared compounds are of particular interest because they might serve as DNA intercalators in anticancer therapy.
Keywords: Substituted dihydrothieno[2'; 3':4; 5]thieno[2; 3-c]quinolin-6-ones; Tetra- hydrodithieno[2; 3-b:2'; 3'-d]thieno[2''; 3''c:2''; 3''c’]diquinolin-6; 14-dione; Synthesis; Photo- chemical synthesis; DNA Intercalators; Anticancer therapy. Substituted dihydrothieno[2'; 3':4; 5]thieno[2; 3-c]quinolin-6-ones; Tetra- hydrodithieno[2; 3-b:2'; 3'-d]thieno[2''; 3''c:2''; 3''c’]diquinolin-6; 14-dione; Synthesis; Photo- chemical synthesis; DNA Intercalators; Anticancer therapy.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Šafarik, J.B.; Koružnjak, J.D.; Karminski-Zamola, G. Chemical and Photochemical Synthesis of Substituted Dihydro-thieno[2',3':4,5]thieno[2,3-c]quinolin-6-ones and Tetrahydro-dithieno[2,3-b:2',3'-d]thieno[2'',3''c:2'',3''c’]diquinolin-6,14-dione. Molecules 2005, 10, 279-288.

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