Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS

doi:10.3390/10010162

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Molecules 2005, 10(1), 162-180; doi:10.3390/10010162

Review

Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS

Hiroko Shibata ¹, Shinsaku Nakagawa ¹ and Yasuo Tsutsumi ¹^,*

¹ Graduate School of Pharmaceutical Sciences, Osaka University. 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan ² National Institute of Health Sciences, Osaka Branch Fundamental Research Laboratories for Development of Medicine. 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085 Japan

* Author to whom correspondence should be addressed.

Received: 30 June 2004; in revised form: 27 September 2004 / Accepted: 12 December 2004 / Published: 31 January 2005

(This article belongs to the Special Issue Macromolecules Applied to Pharmaceutical Chemistry)

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Abstract: Due to recent advances in disease proteomics, many disease-related proteins have been found. It is expected that there will be therapeutically useful proteins among them. However, it is clinically difficult to use most proteins as effective and safe drugs because of their very low stability and pleiotropic actions in vivo. To promote disease proteomic based drug development for protein therapies, we have attempted to develop an optimal polymer-conjugation system for improving the therapeutic potency of proteins. In this review, we introduce this innovative protein-drug system.

Keywords: PEGylation; polyvinyl pyrrolidone; Tumor necrosis factor-alpha; Interluekin-6.

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MDPI and ACS Style

Shibata, H.; Nakagawa, S.; Tsutsumi, Y. Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS. Molecules 2005, 10, 162-180.

AMA Style

Shibata H., Nakagawa S., Tsutsumi Y. Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS. Molecules. 2005; 10(1):162-180.

Chicago/Turabian Style

Shibata, Hiroko; Nakagawa, Shinsaku; Tsutsumi, Yasuo. 2005. "Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS." Molecules 10, no. 1: 162-180.

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