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Entropy 2017, 19(12), 672; doi:10.3390/e19120672

Association between Multiscale Entropy Characteristics of Heart Rate Variability and Ischemic Stroke Risk in Patients with Permanent Atrial Fibrillation

Graduate School of Science and Technology, Kwansei Gakuin University, Sanda 669-1337, Japan
Department of Cardiology, Fujita Health University School of Medicine, Toyoake 470-1192, Japan
Graduate School of Engineering Science, Osaka University, Toyonaka 560-8531, Japan
Author to whom correspondence should be addressed.
Received: 6 November 2017 / Revised: 1 December 2017 / Accepted: 6 December 2017 / Published: 7 December 2017
(This article belongs to the Special Issue Information Theory Applied to Physiological Signals)
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Multiscale entropy (MSE) profiles of heart rate variability (HRV) in patients with atrial fibrillation (AFib) provides clinically useful information for ischemic stroke risk assessment, suggesting that the complex properties characterized by MSE profiles are associated with ischemic stroke risk. However, the meaning of HRV complexity in patients with AFib has not been clearly interpreted, and the physical and mathematical understanding of the relation between HRV dynamics and the ischemic stroke risk is not well established. To gain a deeper insight into HRV dynamics in patients with AFib, and to improve ischemic stroke risk assessment using HRV analysis, we study the HRV characteristics related to MSE profiles, such as the long-range correlation and probability density function. In this study, we analyze the HRV time series of 173 patients with permanent AFib. Our results show that, although HRV time series in patients with AFib exhibit long-range correlation (1/f fluctuations)—as observed in healthy subjects—in a range longer than 90 s, these autocorrelation properties have no significant predictive power for ischemic stroke occurrence. Further, the probability density function structure of the coarse-grained times series at scales greater than 2 s is dominantly associated with ischemic stroke risk. This observation could provide valuable information for improving ischemic stroke risk assessment using HRV analysis. View Full-Text
Keywords: heart rate variability; multiscale entropy; long-range correlation heart rate variability; multiscale entropy; long-range correlation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Matsuoka, R.; Yoshino, K.; Watanabe, E.; Kiyono, K. Association between Multiscale Entropy Characteristics of Heart Rate Variability and Ischemic Stroke Risk in Patients with Permanent Atrial Fibrillation. Entropy 2017, 19, 672.

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