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Medicina 2018, 54(3), 37; https://doi.org/10.3390/medicina54030037

The Clinical Importance of Cystatin C and Hepatic Artery Resistive Index in Liver Cirrhosis

1
Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, School of Medicine-University of Belgrade, 11000 Belgrade, Serbia
2
Institute of Medical Biochemistry, Clinical Center of Serbia, 11000 Belgrade, Serbia
3
Special Hospital for Addiction Diseases “Drajzerova”, 11000 Belgrade, Serbia
4
Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy-University of Belgrade, 11000 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
Received: 26 February 2018 / Revised: 19 May 2018 / Accepted: 24 May 2018 / Published: 28 May 2018
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Abstract

Background: Data suggest cystatin C (CysC) levels and hepatic artery resistive index (HARI) correspond to the progression of chronic liver disease. We aimed to evaluate the clinical significance of these parameters in assessment of fibrosis in patients with liver cirrhosis. Methods: The cross-sectional study included 63 patients with liver cirrhosis. A control group consisted of 30 age- and gender-matched healthy persons. Results: We confirmed significantly higher values of CysC in patients with cirrhosis compared to control group (p = 0.036). Average value of HARI in the examined group was increased (0.72 ± 0.06) and there was the statistically significant difference compared to controls (0.66 ± 0.03) (p < 0.001). We found statistically significant correlation between HARI and CysC in the study group. Analyzing the possibility of distinguishing healthy subjects from patients with fibrosis, we have found that the area under the curve is far greater in the HARI index than CysC. Comparison of CysC among Child–Pugh stages and correlation with a model for end-stage liver disease (MELD) score showed statistically significant results. Conclusion: We confirmed HARI is a more accurate parameter than CysC in discriminating healthy subjects from patients with fibrosis, while CysC could be a better indicator of the stage of liver cirrhosis. View Full-Text
Keywords: Cystatin C; hepatic artery resistive index; liver cirrhosis Cystatin C; hepatic artery resistive index; liver cirrhosis
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Stulic, M.; Culafic, D.; Obrenovic, R.; Jankovic, G.; Alempijevic, T.; Lalosevic, M.S.; Dostanic, N.; Kovacevic, S.V.; Culafic, M. The Clinical Importance of Cystatin C and Hepatic Artery Resistive Index in Liver Cirrhosis. Medicina 2018, 54, 37.

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