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Medicina 2018, 54(1), 4; https://doi.org/10.3390/medicina54010004

Differences in Risk Factors and Prevalence of Vascular Calcification between Pre-Dialysis and Hemodialysis Balkan Nephropathy Patients

1
Fresenius Medical Care Dialysis Center, 76230 Šamac, The Republic of Srpska, Bosnia and Herzegovina
2
Faculty of Medicine, University of East Sarajevo, 73300 Foča, The Republic of Srpska, Bosnia and Herzegovina
3
School of Medicine, University of Belgrade, 11000 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
Received: 31 August 2017 / Revised: 15 March 2018 / Accepted: 16 March 2018 / Published: 19 March 2018
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Abstract

Aims: The aim of this study was to compare the risk factors and prevalence of vascular calcification (VC) in pre-dialysis and hemodialysis (HD) patients with Balkan endemic nephropathy (BEN) or other kidney diseases (non-BEN). Materials and Methods: The study involved 115 patients, 32 pre-dialysis and 83 HD patients, separated into groups of BEN and non-BEN patients. In addition to interviews, objective examinations and laboratory analyses, VC was assessed using Adragao score. Results: Patients with BEN were significantly older in both groups, while pre-dialysis BEN patients had significantly lower systolic blood pressure, serum cholesterol and phosphorus levels, but higher urinary excretion of phosphorus than non-BEN patients. These differences were lost in HD groups. In pre-dialysis patients, prevalence of VC was lower in BEN than in non-BEN group and mean VC score differed significantly between them (2.8 (1.7) vs. 4.6 (1.8); p = 0.009). No significant difference in VC score was found between BEN and non-BEN patients on HD. Multivariate analysis showed that in pre-dialysis patients VC score >4 was associated with lower iPTH and higher serum cholesterol level, but in the HD group with higher serum triglyceride level and longer HD vintage. Conclusions: Lower prevalence of risk factors for VC in the BEN than non-BEN patients was found in pre-dialysis but not in HD group and this was reflected in the prevalence and severity of VC in the groups. Prevalence of VC and mean VC score were significantly lower in pre-dialysis BEN than in non-BEN patients but not for those on HD. View Full-Text
Keywords: Balkan endemic nephropathy; hemodialysis; pre-dialysis patients; vascular calcification Balkan endemic nephropathy; hemodialysis; pre-dialysis patients; vascular calcification
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Petković, N.; Ristić, S.; Marinković, J.; Marić, R.; Kovačević, M.; Djukanović, L. Differences in Risk Factors and Prevalence of Vascular Calcification between Pre-Dialysis and Hemodialysis Balkan Nephropathy Patients. Medicina 2018, 54, 4.

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