Alternans in atria: Mechanisms and clinical relevance
AbstractAtrial fibrillation is the most common sustained arrhythmia and its prevalence is rapidly rising with the aging of the population. Cardiac alternans, defined as cyclic beat-to-beat alternations in contraction force, action potential (AP) duration and intracellular Ca2+ release at constant stimulation rate, has been associated with the development of ventricular arrhythmias. Recent clinical data also provide strong evidence that alternans plays a central role in arrhythmogenesis in atria. The aim of this article is to review the mechanisms that are responsible for repolarization alternans and contribute to the transition from spatially concordant alternans to the more arrhythmogenic spatially discordant alternans in atria. View Full-Text
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Kanaporis, G.; Blatter, L.A. Alternans in atria: Mechanisms and clinical relevance. Medicina 2017, 53, 139-149.
Kanaporis G, Blatter LA. Alternans in atria: Mechanisms and clinical relevance. Medicina. 2017; 53(3):139-149.Chicago/Turabian Style
Kanaporis, Giedrius; Blatter, Lothar A. 2017. "Alternans in atria: Mechanisms and clinical relevance." Medicina 53, no. 3: 139-149.